Moharrami P.Unak P.Guldu O.K.Medine E.I.Gumuser G.Bilgin E.S.Aras O.2024-07-222024-07-22201702365731http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15200A theranostic nanoparticle was synthesized based on diethylstilbestrol conjugated with phosphate, copper, and indium (DESCIP) and labelled with 99mTc which can be used for SPECT imaging of ER-enriched cancers. In vitro biological activity of 99mTc-DESCIP was examined in breast adenocarcinoma cells (MCF-7), prostatic carcinoma cells (PC-3), and pulmonary epithelial cells (A-549). In vivo lymph node imaging was performed in normal and receptor blocked female New Zealand rabbits. Results demonstrated that 99mTc-DESCIP and DESCIP has potential for imaging ER-enriched tumors such as breast and prostate tumors, and their metastases in the lung, as well as improving management for their therapies. © 2017, Akadémiai Kiadó, Budapest, Hungary.Englishdiethylstilbestrolestrogen receptorquantum dottechnetium 99mA-549 cell lineanimal experimentArticlecellular distributioncontrolled studydrug cytotoxicitydrug determinationdrug effectfemalein vivo studyisotope labelinglipophilicitymass spectrometryMCF-7 cell linemolecular imagingNew Zealand rabbitnonhumanPC-3 [Human prostate carcinoma] cell lineArticle10.1007/s10967-017-5630-2