Onder E.N.A.Ertan P.2024-07-222024-07-22202103008630http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13139Background Familial Mediterranean fever (FMF) is the most seen monogenic periodic fever syndrome characterised by bouts of fever and serositis. It is known that subclinical inflammation (SI) can persist in the symptom-free period and lead to amyloidosis even under colchicine treatment. This study aimed to evaluate the role of the fibrinogen-to-albumin ratio (FAR) in FMF and its correlation with SI. Material and Methods A total of 112 patients with FMF and 78 controls were enrolled in this retrospective study. Demo-Demographic, laboratory and genetic data were obtained from the hospital records. Results The FAR values of the FMF cases were significantly higher than the control group (p < 0.001). In the FMF group, the patients with SI had higher FAR values than those without SI (p < 0.001). FAR was positively correlated with SI (r = 0.413, p < 0.001). The receiver operating characteristic curve analysis showed that FAR had a higher area under the curve value than albumin and fibrinogen. Conclusion Detecting SI in patients with FMF is crucial in preventing amyloidosis, the most devastating complication of FMF. FAR is a simple, inexpensive, easily obtained indicator which can be used for reflecting SI in FMF. © 2020 American Institute of Physics Inc.. All rights reserved.EnglishAlbuminsFamilial Mediterranean FeverFibrinogenHumansInflammationRetrospective Studiesalbumincolchicinefibrinogenalbuminoidadultamyloidosisarea under the curveArticlechronic disease indicatorchronic inflammationcontrol groupcontrolled studydemographydiagnostic test accuracy studydiagnostic valuedisease associationdisease severity assessmentfamilial Mediterranean feverfamily historyfemalegene mutationgenetic analysisgenetic associationhumanhypoalbuminemiaimmunosuppressive treatmentlaboratory diagnosismajor clinical studymalemedical recordoutpatient departmentperiod prevalenceprotein blood levelprotein functionreceiver operating characteristicretrospective studysubclinical inflammationfamilial Mediterranean fevergeneticsinflammationArticle10.1055/a-1610-9745