Sarikurkcu C.Ozer M.S.Istifli E.S.Sahinler S.S.Tepe B.2024-07-222024-07-22202102546299http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13076Sideritis species have been used for centuries for their antimicrobial, digestive, anti-ulcerogenic and anti-inflammatory properties. Therefore, in this study, it was aimed to evaluate the chemical composition, antioxidant and enzyme inhibitory activities of solvent extracts of S. leptoclada O. Schwarz & P.H. Davis, an endemic species. It was determined that methanol (MeOH) and water extracts contained high amounts of chlorogenic acid and verbascoside, while the ethyl acetate (EtOAc) extract contained high amounts of 4-hydroxybenzoic and vanilic acids. The water extract showed the highest antioxidant activity in almost all parameters. Inhibitory activity of the MeOH extract on tyrosinase was 1.04 mg/ml, which was the highest value in this experiment. On the other hand, in α-amylase inhibitory assay, the EtOAc extract showed an activity of 2.21 mg/ml. Docking analysis showed that verbascoside can be an effective tyrosinase and α-amylase inhibitory agent. © 2021 SAABEnglishAll Open Access; Hybrid Gold Open AccessTurkeyacetateantioxidantendemic speciesenzyme activitymethanolplantplant extractsolventArticle10.1016/j.sajb.2021.03.020