Mete M.Aydemir I.Unsal U.U.Collu F.Vatandas G.Gurcu B.Duransoy Y.K.Taneli F.Tuglu M.I.Selcuki M.2024-07-222024-07-22201810195149http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15138AIM: To evaluate the neuroprotective effects of deocanthal OC in a rat model of traumatic brain injury (TBI). MATERIAL and METHODS: Twenty-six adult male, Wistar albino rats were used. The rats were divided into 4 groups. Group 1 was the sham group (n = 5). Group 2 was the trauma group (n = 5) where rats were treated with 10 mg/kg saline intraperitoneally (IP) twice a day. Groups 3 and 4, rats were treated with 10 (group 3, n = 8) or 30 (group 4, n = 8) mg/kg OC IP twice a day. For each group, brain samples were collected 72 hours after injury. Brain samples and blood were evaluated with histopathological and biochemical methods. RESULTS: Histopathological evaluation revealed a significant difference between Group 2 and Group 4. Biochemical findings demonstrated that the oxidative stress index was highest in Group 2 and lowest in Group 4. CONCLUSION: OC has a protective effect on neural cells after TBI. This effect is achieved by reducing oxidative stress and apoptosis. © 2018 Turkish Neurosurgical Society.EnglishAll Open Access; Bronze Open Access; Green Open AccessAldehydesAnimalsApoptosisBrainBrain Injuries, TraumaticDisease Models, AnimalMaleNeuroprotective AgentsOlive OilOxidative StressPhenolsRatsRats, Wistaraldehydeneuroprotective agentoleocanthalolive oilphenol derivativeanimalapoptosisbrainchemistrydisease modeldrug effectmaleoxidative stresspathologyrattraumatic brain injuryWistar ratArticle10.5137/1019-5149.JTN.21417-17.2