Yenil N.Ay E.Ay K.Oskay M.Maddaluno J.2024-07-222024-07-22201000086215http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18355The synthesis of 5-amino-5-deoxy-1,2-O-(S)-trichloroethylidene-β-l-arabinofuranose and 6-amino-6-deoxy-1,2-O-(S)-trichloroethylidene-α-d-glucofuranose is described by a simple three- or four-step route. Antibacterial potency of the new compounds was determined using an inhibition zone diameter test. The results show that these compounds have a broad-spectrum activity against Gram-positive, Gram-negative bacteria and Candida albicans. © 2010 Elsevier Ltd. All rights reserved.EnglishAmino SugarsAnti-Infective AgentsBacteriaChloraloseFungiMicrobial Sensitivity TestsStereoisomerismCandida albicansNegibacteriaPosibacteriaAminesBacteriaSugar (sucrose)1,2 o trichloroethylidene beta levo arabinofuranose3,5 di o acetyl trichloroethylidene beta levo arabinofuranose5 acetamido 5 deoxy 3 o acetyl 1,2 o trichloroethylidene beta levo arabinofuranose5 amino 5 deoxy 1,2 o trichloroethylidene beta levo arabinofuranose5 azido 5 deoxy 1,2 o trichloroethylidene beta levo arabinofuranose5 o tosyl 1,2 o trichloroethylidene beta levo arabinofuranose6 acetamido 6 deoxy 3,5 di o acetyl 1,2 o trichloroethylidene alpha dextro glucofuranose6 amino 6 deoxy 1,2 o trichloroethylidene alpha dextro glucofuranose6 azido 6 deoxy 1,2 o trichloroethylidene alpha dextro glucofuranose6 o tosyl 1,2 o trichloroethylidene alpha dextro glucofuranoseaminosugarantibiotic agentcarbohydrate derivativechloralosechloramphenicolnalidixic acidnystatinunclassified drugaminosugarantiinfective agentAmino sugarAnti-microbial activityCandida albicansGram-negative bacteriaInhibition zonesantibacterial activityarticleBacillus cereusBacillus subtilisCandida albicanscarbohydrate synthesiscompetitive inhibitioncontrolled studydrug potencydrug structuredrug synthesisEnterobacter aerogenesEnterobacter cloacaeEnterococcus faecalisEscherichia coliminimum inhibitory concentrationnonhumanpriority journalProteus vulgarisSalmonella typhimuriumStaphylococcus aureusanalogs and derivativesBacteriachemistrydrug effectsfungusmicrobial sensitivity teststereoisomerismsynthesisComplexationArticle10.1016/j.carres.2010.03.043