Gumuser G.Parlak Y.Topal G.Aras F.Ruksen E.Sayit E.2024-07-222024-07-22200901433636http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18707Objective Nuclear medicine procedures are often performed in close-time proximity to bone densitometry studies. The purpose of this study was to determine the effects of 99m99mTc-hexakis-2-methoxyisobutyl isonitrile (MIBI) and 99m99mTc-methylene diphosphonate (MDP) on the accuracy of bone mineral density (BMD) measurements performed using dual-energy X-ray density. Methods The effect of a diagnostic dose of 99m 99mTc-MIBI on BMD estimations in the lumbar spine and the left total hip was assessed in 30 patients (19 female, 11 male; mean age: 55.5 ±±10.5 years) by using a Lunar DPX-NT scanner. Thirty patients, admitted to the nuclear medicine department for bone scintigraphy (15 female, 15 male; mean age: 56 ± 15.92 years), were included into the study. Each patient underwent dual-energy X-ray density assessment for which a Lunar DPX-NT scanner was used before and 2 h after intravenous injection of 99m 99mTc-MDP (925MBq) and 99m99mTc-MIBI (1110MBq). BMD measurements were calculated from lumbar spine (including L2-4) and left hip (including femoral neck, trochanter, and total hip). For statistical analysis, the Wilcoxon test was used and a P value of less than 0.05 was accepted as statistically significant. Results According to Wilcoxon's statistical test, we found extremely significant changes on the measured BMD, T-score, before and 2h after the injection of 99m99mTc-MIBI for lumbar spine and left hip in 30 patients. We found statistically significant decrement on measured BMD from lumbar spine and trochanter before and 2 h after the injection of 99m 99mTc-MDP. Although MDP BMD values in femoral neck and total hip were decreased after the injection of Tc-99m, they did not reach a statistically significant value. The comparison of pre-T-score and post-T-score values showed a statistically significant decrease after the injection for only L2-4 lumbar spine (P= 0.002), but left hip of pre-T-score and post-T-score values did not reach a statistically significant value. © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.EnglishAbsorptiometry, PhotonArtifactsBone and BonesBone DensityFemaleHumansMaleMiddle AgedMyocardial Perfusion ImagingNuclear MedicineSensitivity and SpecificityTechnetium Tc 99m MedronateTechnetium Tc 99m Sestamibimedronate technetium tc 99mmethoxy isobutyl isonitrile technetium tc 99mdiagnostic agentmedronate technetium tc 99mmethoxy isobutyl isonitrile technetium tc 99madultarticlebone densitybone scintiscanningclinical articlediagnostic accuracydrug efficacydual energy X ray absorptiometryfemalefemur neckhiphospital admissionhumanlumbar spinemalemeasurementoutcome assessmentpatient assessmentradioactivityscintillation cameraartifactboneclinical trialdrug effectheart scintiscanningmiddle agednuclear medicinephoton absorptiometryphysiologyscintiscanningsensitivity and specificityArticle10.1097/MNM.0b013e328329fc4c