Kaba M.Pirincci N.Benli E.Gecit I.Gunes M.Yuksel M.B.Tok A.Kemik A.S.2024-07-222024-07-22201415137368http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16979Background: Evidence indicates that Dickkopf-1 (DKK-1) levels may be a biomarker for cancer risk. The aim of this study was to assess DKK-1 and its correlation with clinic-pathological features in patients with bladder cancer. Materials and Methods: DKK-1 levels were determined in serum samples from 90 patients with bladder cancer before transurethral tumor resection. The concentrations of DKK-1 were determined by using enzyme linked immune-sorbent assay (ELISA). Results: Elevated preoperative DKK-1 levels were associated with tumor stage (p<0.001), grade (p<0.001) and histological grade (p<0.001). Conclusions: The results of our study demonstrated that the level of serum DKK-1 is correlated with both disease progression and increase in the tumor grade. Preoperative serum DKK-1 elevation may thus represent a novel marker for the determination of bladder cancer and the detection of patients with a likely poor clinical outcome.EnglishAll Open Access; Gold Open Access; Green Open AccessAdultAgedFemaleHumansIntercellular Signaling Peptides and ProteinsLymphatic MetastasisLymphatic VesselsMaleMiddle AgedNeoplasm InvasivenessTumor BurdenTumor Markers, BiologicalTurkeyUrinary Bladder NeoplasmsDKK1 protein, humansignal peptidetumor markeradultagedarticlebladder tumorbloodfemalehumanlymph node metastasislymph vesselmalemiddle agedpathologytumor invasiontumor volumeTurkey (republic)Article10.7314/APJCP.2014.15.1.381