Erol A.2024-07-222024-07-22200703069877http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19358FOXO transcription factors and evolutionarily conserved c-jun N-terminal kinase (JNK) could hold the key to counteract hormetic anti-aging and common diseases. Hormesis is increasingly recognized as a mechanism underlying the beneficial anti-aging effects of certain genetic and environmental factors. Caloric restriction and exercise increase the resistance of organisms to stress and activate stress resistance pathways in cells in different tissues throughout the body by hormesis based mechanism. JNK triggers the relocalization of FOXO factors to the nucleus inducing the expression of FOXO dependent stress response and damage repairing genes. This adaptive response to stress stimuli may play an important role in regulating homeostasis at the organismal level and contribute to longevity.EnglishAgingCell AgingEvolutionForkhead Transcription FactorsHumansJNK Mitogen-Activated Protein KinasesLongevityModels, BiologicalOxidative StressSignal Transductionchaperonepolydeoxyribonucleotide synthasereactive oxygen metabolitestress activated protein kinasetranscription factor FKHRtranscription factor FKHRL1transcription factor FOXOagingcaloric restrictioncell levelenvironmental factorexercisehemodynamicsheredityhomeostasishormesisletterlifespanmetabolic stressoxidative stresspleiotropypriority journalsurvivaltemperature stressupregulationLetter10.1016/j.mehy.2006.09.022