Deliormanlı A.M.2024-07-222024-07-22201509574530http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16398Bioactive glasses are widely used in biomedical applications due to their ability to bond to bone and even to soft tissues. In this study, borate based (13-93B3) bioactive glass powders containing up to 5 wt% Ce2O3 and Ga2O3 were prepared by the melt quench technique. Cerium (Ce+3) and gallium (Ga+3) were chosen because of their low toxicity associated with bacteriostatic properties. Bioactive glass scaffolds were fabricated using the polymer foam replication method. In vitro degradation and bioactivity of the scaffolds were evaluated in SBF under static conditions. Results revealed that the cerium- and gallium-containing borate glasses have much lower degradation rates compared to the bare borate glass 13-93B3. In spite of the increased chemical durability, substituted glasses exhibited a good in vitro bioactive response except when the Ce2O3 content was 5 wt%. Taking into account the high in vitro hydroxyapatite forming ability, borate glass scaffolds containing Ce+3 and Ga+3 therapeutic ions are promising candidates for bone tissue engineering applications. © 2015, Springer Science+Business Media New York.EnglishBody FluidsBone SubstitutesBoratesCeriumDurapatiteEquipment DesignEquipment Failure AnalysisGalliumGlassHardnessMaterials TestingTissue EngineeringTissue ScaffoldsBioactive glassBiodegradationCerium compoundsDegradationHydroxyapatiteMedical applicationsScaffolds (biology)Tissuecerium containing borate glassgallium containing borate glassglasshydroxyapatiteunclassified drugbone prosthesisboric acidceric oxideceriumgalliumgallium oxideglassBacteriostatic propertiesBiomedical applicationsBone tissue engineeringChemical durabilityDegradation rateReplication methodStatic conditionsSynthesis and characterizationsArticlebiological activitybone tissuedegradationfoamhumanhuman tissuein vitro studypriority journalsynthesistissue engineeringbody fluidbone prosthesischemistrydevice failure analysisdevicesequipment designhardnessmaterials testingtissue engineeringtissue scaffoldGallium compoundsArticle10.1007/s10856-014-5368-0