Tosun S.Deveci S.Kaplan Y.Kasirga E.2024-07-222024-07-22201013000381http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18333Objective: It was aimed to investigate effects of Massive vaccinetion has been performing since 1998 in our country, to HBC seroprevalences according to socio-economic levels of children that de living in Manisa. Material and Methods: The study is a descriptive, cross-sectional field research. The study population was students, who were at the 3rd, 4th, 5th, and 6th grades of public primary schools in Manisa City Centren. Schools were classified in to three subcategories as low, intermediate and high level depending on the socio-economic level of the regions. Results: The number of the participating children in the study was 1504; 50.3%(n= 756) of this number comprised of boys and 49.7%(n= 748) of it comprised of girls. When the distribution according to socio-economic level is evaluated, the numbers of the children from high, intermediate and low level of socio-economic level were 16.2%(n= 243), 43.8%(n= 660) and 40.0%(n= 601), respectively. The carrier state rate according to year of birth from 1996 to 1999 are 1.7%, 1.5%, 1.1%and 0.8%respectively; where as the ratios of antibody titration at preventive level (>10 IU/mL) were 29.6%, 40.1%, 71.5% and 65.8%, res pectively (F= 84.40, p= 0.000). Depending on the results of last model with degraded logistic regression, to be born in pre-mass vaccination period was 4.01 times (95%GA: 3.19-5.05) riskier comparing to be born in mass vaccination period, whereas being in low socio-economic level was 4.25 times (95%GA: 3.36-5.36) riskier comparing to being in high-intermediate socioeconomic level in terms of sensitivity to he patitis B. Conclusion: As a conclusion, mass HBV vaccination, which has been employed for 10 years in our country, has caused a significant decrease in HBsAg positivity, especially in the childhood. Therefore, it should be maintained likewise with high vaccination rates. In addition, HBsAg screening of all pregnant women and sufficient immunization (vaccine and HBIG) of the new borns from baby carriers should not be disregarded at the birth. Copyright © 2010 by Türkiye Klinikleri.Turkishhepatitis B surface antigenhepatitis B vaccineantibody titerarticlechildcross-sectional studydisease associationdisease carrierfemalehepatitis Bhumanmajor clinical studymalemass immunizationprimary schoolschool childseroprevalencesocioeconomicsvaccinationArticle