Türkkanı G.Güngör B.Cetin O.İçhedef Ç.Parlak Y.Gümüşer F.G.Sayıt Bilgin B.E.Teksöz S.2025-04-102025-04-102023http://hdl.handle.net/20.500.14701/44551In this study, it is aimed to design a smart drug delivery system for the diagnosis and treatment of cancer cells. Magnetic-solid lipid nanoparticles were synthesized as a drug delivery system and azathioprine (AZA) was loaded into this system. This newly created system was radiolabeled using technetium-99 m with a radiolabeling yield of 90.3%. Drug loading into the SLMNP was found as 86%. The biological behavior of 99mTc and radiolabeled magnetic solid lipid nanoparticles loaded with azathioprine (99mTc-AZA-SLMNP) was investigated in vitro and in vivo. Graphical abstract: [Figure not available: see fulltext.] © 2023, Akadémiai Kiadó, Budapest, Hungary.Article10.1007/s10967-023-08975-5