Tekin S.G.Topçu I.Kefi A.Enrinçler T.2024-07-222024-07-22200613000578http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19488Background: In this study, the analgesic and side effects of bupivacaine with combinations of ketamine and fentanyl using patient-controlled-epidural analgesia (PLEA) methods in the postoperative period of total abdominal hysterectomy (TAH) operations were compared. Method: Sixty ASA I-II patients aged between 18-65 years were included, Following epidural catheterization the patients were operated under general anesthesia, After surgery, patients were randomly allocated to 3 groups in a double-blinded fashion to receive PCEA as Group B: 0.125% bupivacaine, Group BF: 0.125% bupivacaine plus 0.1 mg fentanyl and Group BK.: 0.125% bupivacaine plus 40 mg ketamine solutions (10 mL loading dose, 5 mL bolus dose, 10 min lockout time, 30 mL in a 4 hour limit) in 100 mL salin. Hemodynamic parameters, VAS scores, total analgesic consumption, additional analgesic requirements, sedation scores, satisfaction scores and probable side-effects were evaluated for 24 h. Results: Total analgesic consumption was lower in the fentanyl group (p<0.05), Therefore VAS scores in the fentanyl group were lower than the other groups at the 1 hour and the 24 hour assessments (p<0.05), Postoperative analgesic consumption was lower in the ketamine group compared to the control group, There was no difference in side effects and additional analgesic requirement between the groups. Conclusion: Fentanyl and ketamine may be used safely by PCEA for postoperative analgesia, These adjuncts increase analgesic quality and patient satisfaction without increased side effects.Turkishbupivacainefentanylketaminesodium chlorideabdominal hysterectomyadjuvant therapyadultagedanalgesic activityarticleclinical trialcontrolled clinical trialcontrolled studydouble blind proceduredrug safetyepidural anesthesiaepidural catheterfemalegeneral anesthesiahemodynamicshumanmajor clinical studypatient controlled analgesiapatient satisfactionpostoperative analgesiapostoperative painpostoperative periodrandomized controlled trialsedationstatistical significanceunspecified side effectvisual analog scaleArticle