Erol, A2024-07-182024-07-181687-47571687-4765http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/5834Peroxisome proliferator-activated receptor beta/delta (PPAR beta/delta) has emerged as a powerful metabolic regulator in diverse tissues including fat, skeletal muscle, and the heart. It is now established that activation of PPAR beta/delta promotes fatty acid oxidation in several tissues, such as skeletal muscle and adipose tissue. In muscle, PPAR beta/delta appears to act as a central regulator of fatty acid catabolism. PPAR beta/delta contents are increased in muscle during physiological situations such as physical exercise or long-term fasting, characterized by increased fatty acid oxidation. Targeted expression of an activated form of PPAR beta/delta in skeletal muscle induces a switch to form increased numbers of type I muscle fibers resembling the fiber type transition by endurance training. Activation of PPAR beta/delta also enhances mitochondrial capacity and fat oxidation in the skeletal muscle that resembles the effect of regular exercise. Therefore, it is hypothesized that muscle-specific PPAR beta/delta agonists could be a key strategy to support the poor cardiorespiratory fitness associated with metabolic disorders. Copyright (C) 2007 Adnan Erol.EnglishACTIVATED-RECEPTOR-DELTAOXIDATIVE ENZYME-ACTIVITYSKELETAL-MUSCLEFIBER-TYPEINSULIN-RESISTANCEGENE-EXPRESSIONEXERCISEALPHAGAMMABETAReview