Öztürk, FErmertcan, AT2024-07-182024-07-181556-9527http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/4252Cutaneous wound healing is a complex and well-coordinated interaction between inflammatory cells and mediators, establishing significant overlap between the phases of wound healing. Wound healing is divided into three major phases: inflammatory phase, proliferative phase, and remodeling phase. Unlike the acute wound, the nonhealing wound is arrested in one of the phases of healing, typically the inflammatory phase. A systematic approach to the management of the chronic nonhealing wound emphasizes three important elements of wound bed preparation in chronic wounds: debridement, moisture, and countering bacterial colonization and infection. In this article, wound-healing process and new approaches to the topical wound care have been reviewed.EnglishNITRIC-OXIDE-SYNTHASEGROWTH-FACTOR-BETAMATRIX METALLOPROTEINASESRECEPTOR EXPRESSIONBED PREPARATIONIN-VITROMANAGEMENTDRESSINGSDISEASEBIOLOGYReview