Comparison of high-sensitivity C-reactive protein and fetuin-A levels before and after treatment for subjects with subclinical hyperthyroidism

Bilgir O.Bilgir F.Topcuoglu T.Calan M.Calan O.2024-07-222024-07-2220141355008Xhttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17019This study was designed to show the effect of propylthiouracil treatment on sCD40L, high-sensitivity C-reactive protein, and fetuin-A levels on subjects with subclinical hyperthyroidism. After checking sCD40L, high-sensitivity C-reactive protein, and fetuin-A levels of 35 patients with subclinical hyperthyroidism, each was given 50 mg tablets of propylthiouracil three times daily. After 3 months, sCD40L, high-sensitivity C-reactive protein, and fetuin-A levels were then compared to the levels before treatment. Although high-sensitivity C-reactive protein and sCD40L levels were normal in the subclinical hyperthyroidism patients compared to the healthy controls, fetuin-A levels were statistically significantly higher (*p = 0.022). After treatment, fetuin-A levels of subclinical hyperthyroidism patients decreased statistically significantly compared to the levels before treatment (**p = 0.026). sCD40L and high-sensitivity C-reactive protein levels did not have a statistically significant difference compared to the control group and post-propylthiouracil treatment. In subclinical hyperthyroidism patients, high fetuin-A levels before propylthiouracil treatment and decreases in these levels after treatment in cases with subclinical hyperthyroidism indicated the possibility of preventing long-term cardiac complications with propylthiouracil treatment. © 2013 Springer Science+Business Media New York.EnglishAdultalpha-2-HS-GlycoproteinAntithyroid AgentsBiological MarkersC-Reactive ProteinCase-Control StudiesCD40 LigandDose-Response Relationship, DrugFemaleHumansHyperthyroidismMalePropylthiouracilRetrospective StudiesTreatment OutcomeC reactive proteinCD40 ligandfetuin Aliothyroninepropylthiouracilthyrotropinthyroxineadultarticlechemiluminescence analyzerchemiluminescence immunoassayclinical articlecontrolled studyELISA kitenzyme linked immunosorbent assayfemalehumanliothyronine blood levelmalepriority journalprotein blood levelsubclinical hyperthyroidismsubclinical hypothyroidismthyrotropin blood levelthyroxine blood leveltreatment durationtreatment outcomeComparison of high-sensitivity C-reactive protein and fetuin-A levels before and after treatment for subjects with subclinical hyperthyroidismArticle10.1007/s12020-013-9993-z