Eskiizmir G.Gençoǧlan G.Temiz P.Hirçin Z.Ermertcan A.2024-07-222024-07-22201109374477http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18182The objective of the study was to investigate the effect of staged-surgery with permanent pathology on tumour recurrence of high-risk nonmelanoma skin cancers (NMSCs) of the nose and to determine the factors associated with subclinical spread and deep-margin involvement. Twenty-one patients who underwent staged-surgery with permanent pathology for high-risk NMSCs of the nose between 2007 and 2008 were prospectively followed-up for tumour recurrence. The incidence of tumour recurrence after staged-surgery with permanent pathology was 0%. A positive correlation between perineural involvement and subclinical spread (p = .012); and a statistically significant relationship between infiltrative type basal cell carcinoma (BCC) and deep-margin involvement (p = .033) was detected. Staged-surgery with permanent pathology is a reliable surgical method for complete excision of high-risk NMSCs of the nose and provides a significant decrease in tumour recurrence. Perineural involvement may cause subclinical spread, and infiltrative type BCC may invade deeper structures of the nose. © 2010 Springer-Verlag.EnglishAdultAgedAged, 80 and overCarcinoma, Basal CellCarcinoma, Squamous CellChi-Square DistributionFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasm InvasivenessNeoplasm Recurrence, LocalNose NeoplasmsProspective StudiesReconstructive Surgical ProceduresRisk FactorsStatistics, NonparametricSurgical FlapsTreatment Outcomeadultagedarticlecancer surgeryclinical articlefemalefollow uphumanmalemetastasisnonmelanoma skin cancernose cancerpriority journalskin cancertumor recurrenceArticle10.1007/s00405-010-1324-x