Öztürk T.Ağdanlı D.Bayturan Ö.Çıkrıkcı C.Keleş G.T.2024-07-222024-07-2220151414431Xhttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16526Myocardial ischemia, as well as the induction agents used in anesthesia, may cause corrected QT interval (QTc) prolongation. The objective of this randomized, double-blind trial was to determine the effects of high- vs conventional-dose bolus rocuronium on QTc duration and the incidence of dysrhythmias following anesthesia induction and intubation. Fifty patients about to undergo coronary artery surgery were randomly allocated to receive conventional-dose (0.6 mg/kg, group C, n=25) or high-dose (1.2 mg/kg, group H, n=25) rocuronium after induction with etomidate and fentanyl. QTc, heart rate, and mean arterial pressure were recorded before induction (T0), after induction (T1), after rocuronium (just before laryngoscopy; T2), 2 min after intubation (T3), and 5 min after intubation (T4). The occurrence of dysrhythmias was recorded. In both groups, QTc was significantly longer at T3 than at baseline [475 vs 429 ms in group C (P=0.001), and 459 vs 434 ms in group H (P=0.005)]. The incidence of dysrhythmias in group C (28%) and in group H (24%) was similar. The QTc after high-dose rocuronium was not significantly longer than after conventional-dose rocuronium in patients about to undergo coronary artery surgery who were induced with etomidate and fentanyl. In both groups, compared with baseline, QTc was most prolonged at 2 min after intubation, suggesting that QTc prolongation may be due to the nociceptive stimulus of intubation. © 2015, Associacao Brasileira de Divulgacao Cientifica. All rights reserved.EnglishAll Open Access; Gold Open Access; Green Open AccessAgedAndrostanolsAnesthesia, GeneralAnesthetics, IntravenousArrhythmias, CardiacArterial PressureCoronary VesselsDouble-Blind MethodElectrocardiographyEtomidateFemaleFentanylHeart RateHumansIntubationLaryngoscopyMaleMiddle AgedNeuromuscular Nondepolarizing AgentsStatistics, Nonparametricetomidatefentanylrocuroniumandrostane derivativeetomidatefentanylintravenous anesthetic agentneuromuscular blocking agentrocuroniumadultanesthesia inductionArticleclinical assessmentclinical trialcontrolled studycoronary artery surgerydouble blind proceduredrug megadoseelectrocardiographyfemaleheart arrhythmiaheart muscle ischemiaheart ratehumanintubationmajor clinical studymalemean arterial pressuremiddle agedoutcome assessmentpatient monitoringQT prolongationrandomized controlled trialadverse effectsagedArrhythmias, Cardiacarterial pressurecoronary blood vesseldrug effectsgeneral anesthesiaintubationlaryngoscopynonparametric testproceduressurgeryArticle10.1590/1414-431X20144294