Bilgir F.Bilgir O.Calan M.Calan O.Isikyakar T.2024-07-222024-07-22201403000605http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16912Objective: Adhesion molecules are involved in inflammation, atherosclerosis and malignancy. This study measured levels of adhesion molecules before and after levothyroxine therapy in patients with subclinical hypothyroidism (SHO). Methods: Levels of soluble (s) intracellular adhesion molecule (ICAM)-1, s vascular cell adhesion molecule (sVCAM) VCAM-1 and sE-selectin were analysed in patients diagnosed with SHO, prior to administration of 50 mg/day levothyroxine orally for 3 months. Subsequently, levels of sICAM-1, sVCAM-1 and sE-selectin were reanalysed then compared with the pretreatment levels. Results: In 30 patients with SHO, levels of sICAM-1 were found to be significantly higher than those in healthy controls, (P=0.001). Post-treatment sICAM-1 levels were significantly lower than pretreatment levels (P=0.001). No significant differences were found in sVCAM-1 or sE-selectin levels between healthy controls and patients with SHO before treatment, or between patients with SHO pre- and post-treatment. Conclusions: Patients with SHO had significantly higher levels of sICAM-1 compared with controls. Levels became normal after treatment with levothyroxine. These findings emphasize the need for levothyroxine therapy in cases of SHO to normalize sICAM-1 levels. Such treatment helps to prevent the future development of atherosclerosis or cancer. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.EnglishAdultAsymptomatic DiseasesCase-Control StudiesDrug Administration ScheduleE-SelectinFemaleHumansHypothyroidismIntercellular Adhesion Molecule-1MaleMiddle AgedThyrotropinThyroxineTreatment OutcomeTriiodothyronineVascular Cell Adhesion Molecule-1endothelial leukocyte adhesion molecule 1intercellular adhesion molecule 1levothyroxineliothyroninethyrotropinthyroxinevascular cell adhesion molecule 1endothelial leukocyte adhesion molecule 1ICAM1 protein, humanintercellular adhesion molecule 1liothyroninethyrotropinthyroxinevascular cell adhesion molecule 1adultarticleclinical articlecomparative studycontrolled studyfatiguefemalefree thyroxine indexHashimoto diseasehumanimmunoassay analyzerliothyronine blood levelmalemorbiditysubclinical hypothyroidismthyrotropin blood leveltreatment durationweight gainasymptomatic diseasebloodcase control studydrug administrationhypothyroidismmiddle agedtreatment outcomeArticle10.1177/0300060514526566