Gunduz R.Yildiz B.S.Ozdemir I.H.Cetin N.Ozen M.B.Bakir E.O.Ozgur S.Bayturan O.2024-07-222024-07-22202109295305http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13268In this study, we investigated whether the CHA2DS2-VASc score could be used to estimate the need for hospitalization in the intensive care unit (ICU), the length of stay in the ICU, and mortality in patients with COVID-19. Patients admitted to Merkezefendi State Hospital because of COVID-19 diagnosis confirmed by RNA detection of virus by using polymerase chain reaction between March 24, 2020 and July 6, 2020, were screened retrospectively. The CHA2DS2-VASc and modified CHA2DS2-VASc score of all patients was calculated. Also, we received all patients’ complete biochemical markers including D-dimer, Troponin I, and c-reactive protein on admission. We enrolled 1000 patients; 791 were admitted to the general medical service and 209 to the ICU; 82 of these 209 patients died. The ROC curves of the CHA2DS2-VASc and M-CHA2DS2-VASc scores were analyzed. The cut-off values of these scores for predicting mortality were ≥ 3 (2 or under and 3). The CHA2DS2-VASc and M-CHA2DS2-VASc scores had an area under the curve value of 0.89 on the ROC. The sensitivity and specificity of the CHA2DS2-VASc scores were 81.7% and 83.8%, respectively; the sensitivity and specificity of the M-CHA2DS2-VASc scores were 85.3% and 84.1%, respectively. Multivariate logistic regression analysis showed that CHA2DS2-VASc, Troponin I, D-Dimer, and CRP were independent predictors of mortality in COVID-19 patients. Using a simple and easily available scoring system, CHA2DS2-VASc and M-CHA2DS2-VASc scores can be assessed in patients diagnosed with COVID-19. These scores can predict mortality and the need for ICU hospitalization in these patients. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.EnglishAll Open Access; Hybrid Gold Open AccessAdolescentAdultAgedBiomarkersCOVID-19Decision Support TechniquesFemaleFibrin Fibrinogen Degradation ProductsHospital MortalityHospitalizationHumansIntensive Care UnitsLength of StayMaleMiddle AgedPredictive Value of TestsPrognosisReceptors, ImmunologicRetrospective StudiesRisk AssessmentRisk FactorsThromboembolismTime FactorsTroponin ITurkeyYoung AdultC reactive proteinD dimertroponin Ibiological markerCRP protein, humanfibrin degradation productfibrin fragment Dimmunoglobulin receptortroponin IadultagedArticleCHA2DS2-VASc scorecoronavirus disease 2019femalehospital mortalityhospitalizationhumanintensive care unitlength of staymajor clinical studymalemortalitypredictive valueretrospective studysensitivity and specificityadolescentblooddecision support systemmiddle agedprognosisrisk assessmentrisk factorthromboembolismtime factorturkey (bird)young adultArticle10.1007/s11239-021-02427-1