Altinisik M.Kurt E.Kayikcioglu O.Yildirim A.2024-07-222024-07-22202108820538http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13592Purpose: To analyze early quantitative changes in the choroidal neovascularization (CNV) area observed with optical coherence tomography angiography (OCTA) after single anti-vascular endothelial growth factor (anti-VEGF) injection. Materials and Methods: Treatment-naive patients with CNV secondary to neovascular age-related macular degeneration were analyzed immediately before and ~4 weeks after anti-VEGF injection. The primary endpoints of the study included changes in CNV total and vascular area. Secondary endpoints were best-corrected visual acuity (BCVA), central macular thickness (cMT), central total macular thickness (cTMT), and subfoveal choroidal thickness (SFCT). Results: A total of 27 patients (69.19 ± 5.91 years, 21 men/6 women, 14 type 1 NV, 11 type 2 NV, and 2 type 3 NV) were included in the study. There was a significant increase in BCVA and decreases in cMT, cTMT, and SFCT after treatment (p<0.05 for all). CNV total and vascular area changed by −11.55 ± 44.26% (95% confidence interval [CI]: −29.06 and 5.95; p=0.269) and −21.06 ± 41.2% (95% CI: −36.45/−5.67; p=0.786), respectively. The cases with decreased cTMT were accompanied by a decrease in CNV area only in 37% of the cases. No significant correlation was detected between cTMT and CNV total and vascular area percentage changes (r = −0.06, p=0.74; r = 0.02, p=0.9, respectively). Conclusions: Changes in CNV total and vascular area seem to have limited sensitivity as a biomarker in terms of activation, as wide variability was observed in CNV area after anti-VEGF injection. © 2021 Taylor & Francis.EnglishAngiogenesis InhibitorsChoroidal NeovascularizationFemaleFluorescein AngiographyHumansInfantInfant, NewbornIntravitreal InjectionsMaleRetrospective StudiesTomography, Optical CoherenceVisual Acuitybevacizumabdexamethasonenetilmicintropicamideangiogenesis inhibitoragedArticlebest corrected visual acuitycataract extractioncentral macular thicknessclinical articlecomparative studyconfidence intervalcontrolled studydiabetic retinopathyeye surgeryfemalefollow uphumanmaleobservational studyoptical coherence tomography angiographypatient referralphotodynamic therapyprospective studyquantitative analysisretina vein occlusionretinal pigment epitheliumsubfoveal choroidal thicknesssubretinal fluidsubretinal neovascularizationfluorescence angiographyinfantintravitreal drug administrationnewbornoptical coherence tomographyretrospective studysubretinal neovascularizationvisual acuityArticle10.1080/08820538.2021.1903944