Ermertcan A.T.Hellings P.W.Cingi C.2024-07-222024-07-22201215581926http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17657Nonmelanoma skin cancer (NMSC) is one of the most prevalent types of cancer worldwide, with basal cell carcinoma and squamous cell carcinoma being the most frequent histologic types. Surgical excision remains the mainstay of treatment, but nonsurgical treatment options may be indicated in specific cases. Nonsurgical treatment options for NMSC may be preferred as good alternatives under certain circumstances. This review provides a comprehensive overview of the nonsurgical treatment modalities for NMSCs, such as curettage and electrodesiccation, cryotherapy, radiotherapy, laser, photodynamic therapy, immunotherapy, and retinoid therapy. © 2012 Elsevier Inc.EnglishAge FactorsCarcinoma, Basal CellCarcinoma, Squamous CellCicatrixHead and Neck NeoplasmsHumansNeoplasm InvasivenessRisk FactorsSkin Neoplasmsafamelanotidealpha2a interferonalpha2b interferonaminolevulinic acidbetulic acidbetulincapecitabinecelecoxibcetuximabcyclooxygenase 2 inhibitorcyclopamineepidermal growth factor receptor kinase inhibitorerlotinibfluorouracilgefitinibimiquimodinterferonisotretinoinlupeololeanolic acidpanitumumabphotofrinprotoporphyrinresiquimodretinoic acidretinoidtazaroteneunindexed drugverteporfinvismodegibactinic keratosisbasal cell carcinomacancer mortalitycancer radiotherapycarbon dioxide laserconservative treatmentcryotherapycurettagedesiccationdisease severityelectrodesiccationexternal beam radiotherapyhead and neck cancerhead and neck squamous cell carcinomahumanlasermorbidityneodymium laserneodymium YAG lasernonhumannonmelanoma skin cancerphotodynamic therapyreviewrisk factorskin cancerskin tumorsquamous cell carcinomatreatment responseReview10.1016/j.fsc.2012.08.004