Artunc-Ulkumen B.Guvenc Y.Goker A.Gozukara C.2024-07-222024-07-22201514767058http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16082Objective: The aim of the present study was to evaluate changes in maternal serum neutrophil gelatinase-associated lipocalin (NGAL) and procalcitonin (PCT) concentrations in preeclampsia.Material and method: This case-control study consisted of 40 preeclamptic and 40 healthy singleton pregnancies matched for age and body mass index. Serum NGAL and PCT levels were compared between the groups. Diagnostic performance and clinical association of these markers were evaluated.Results: NGAL and PCT concentrations were significantly higher in preeclamptic group (p < 0.0001 and p = 0.001, respectively) and their levels were correlated with the severity of the preeclampsia. There were significant positive correlation between these markers and mean arterial pressure (MAP) and spot urine protein excretion. There was negative correlation between NGAL and apgar scores and fetal birth weight. Pregnancies with higher NGAL (OR: 4.89; 95% CI: 1.81-13.21) and higher PCT (OR: 6.67; 95% CI: 2.44-18.21) concentrations had higher risk for preeclampsia.Conclusion: NGAL and PCT may be potential biomarkers for preeclampsia. Their levels increase significantly in preeclampsia and they are related to the severity of the disease. These results are in agreement with the generalized endothelial damage and persistant inflammatory status in preeclampsia. NGAL may also be an indicator for adverse neonatal outcomes with decreased placental hypoperfusion. © 2014 Informa UK Ltd.EnglishAcute-Phase ProteinsAdultBiomarkersCalcitoninCase-Control StudiesFemaleHumansLipocalinsPre-EclampsiaPregnancyProtein PrecursorsProto-Oncogene ProteinsSensitivity and SpecificitySeverity of Illness Indexneutrophil gelatinase associated lipocalinprocalcitoninacute phase proteinbiological markercalcitoninLCN2 protein, humanlipocalinoncoproteinprocalcitoninprotein precursoradultArticlebirth weightbody masscase control studyclinical articlecontrolled studydisease associationdisease severityfemalehumanmean arterial pressurepreeclampsiapriority journalprotein blood levelprotein urine levelrisk factorurinary excretionbloodPre-Eclampsiapregnancysensitivity and specificityseverity of illness indexArticle10.3109/14767058.2014.972926