Tuğrul B.Söylev S.Temiz P.Gençoğlan G.2024-07-222024-07-22202002504685http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14226Background: Cutaneous squamous cell carcinoma (cSCC) is a malignant and invasive tumor which is originated from epidermis with a high incidence among non-melanoma skin cancers. The aim of this study was to determine whether vitamin D receptor (VDR), calcium-sensing receptor (CaSR) and beta catenin (β-catenin) proteins have an effect on cSCC. Materials and methods: VDR, CaSR and β-catenin proteins in tissue samples of cSCC and control group were analyzed by immunohistochemistry (IHC) and Western blotting (WB) method. IHC findings were statistically evaluated. Results: IHC staining density of VDR and β-catenin were higher in cSCC tissue samples than control. The difference between IHC staining density of VDR and β-catenin in the patient and the control groups were statistically significant (p = 0.021, p = 0.021, respectively), but not for CaSR (p = 0.237). While the VDR and β-catenin staining rates obtained by the IHC method could be supported by WB results, the WB bands for CaSR could not be shown. Conclusion: The findings suggest that VDR and β-catenin may have an effect on the disease. Further research is required to better understand the role of VDR and β-catenin together on cSCC. © 2020 De Gruyter. All rights reserved.EnglishAll Open Access; Gold Open Accessbeta catenincalcium sensing receptorvitamin D receptorArticlecontrolled studyhistopathologyhumanhuman tissueimmunohistochemistrypolyacrylamide gel electrophoresisprotein analysisprotein determinationprotein localizationskin carcinomasquamous cell carcinomastainingWestern blottingArticle10.1515/tjb-2019-0434