Rulev, AYYenil, NPesquet, AOulyadi, HMaddaluno, J2024-07-182024-07-180040-4020http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/9826The hyperbaric aza-Michael addition of mono- and diamines on alpha,beta-unsaturated beta,beta-disubstituted mono- and diesters has been studied. While in the case of monoester, this reaction provides a beta-aminoester presenting a quaternary center, a direct and efficient access to diester or lactams featuring an azanorbornyl skeleton was obtained when starting from a diester, following an unprecedented double aza-Michael addition. (c) 2006 Elsevier Ltd. All rights reserved.EnglishBETA-AMINO ACIDSASYMMETRIC-SYNTHESISALPHA,BETA-ETHYLENIC ESTERSCONJUGATE ADDITIONFACILE SYNTHESISALPHA-AMINOEPIBATIDINEDERIVATIVESLACTAMSACTIVATIONArticle