Avcibasi, UTürkyarar, TKaradag, ABakan, BYavasoglu, NÜKKusat, KAkgöl, SGülcemal, DTekin, VMüftüler, FZBTopal, GParlak, YGümüser, FG2024-07-182024-07-180236-57311588-2780http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/10375The aim of this study is the synthesis of a novel Tc-99m-labeld graft polymer and the biological evaluation of its in vitro and in vivo properties. To this end, a L-proline-graft-poly(HEMA) was prepared and labeled with Tc-99m. The radiochemical yield of approximately the Tc-99m-labeled compound amounted to 97 +/- 2.3%. The cytotoxicity test revealed no cytotoxic effect after a 24- and 48-h incubation. The results of the hemolysis test showed that hemolysis was non-toxic with an effect level of less than 2%. Subsequently, the biodistribution in healthy rats was determined. High accumulation of the polymer was observed in the pancreas, thyroid and prostate.EnglishMAGNETIC NANOPARTICLESTOXICITYBIODISTRIBUTIONCYTOTOXICITYADSORPTIONDELIVERYPROLINETHERAPYFUTURESIZEArticle