Mesut METEIşıl AYDEMİRÜlkün Ünlü ÜNSALFatih ÇÖLLÜGokhan VATANDASBEYHAN GÜRCÜYusuf Kurtuluş DURANSOYFatma TANELİMehmet İbrahim TUĞLUMehmet SELÇUKİ2024-07-242024-07-2420181019-5149http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/25375AIM: To evaluate the neuroprotective effects of deocanthal OC in a rat model of traumatic brain injury (TBI).MATERIAL and METHODS: Twenty-six adult male, Wistar albino rats were used. The rats were divided into 4 groups. Group 1was the sham group (n=5). Group 2 was the trauma group (n=5) where rats were treated with 10 mg/kg saline intraperitoneally (IP)twice a day. Groups 3 and 4, rats were treated with 10 (group 3, n=8) or 30 (group 4, n=8) mg/kg OC IP twice a day. For each group,brain samples were collected 72 hours after injury. Brain samples and blood were evaluated with histopathological and biochemicalmethods.RESULTS: Histopathological evaluation revealed a significant difference between Group 2 and Group 4. Biochemical findingsdemonstrated that the oxidative stress index was highest in Group 2 and lowest in Group 4.CONCLUSION: OC has a protective effect on neural cells after TBI. This effect is achieved by reducing oxidative stress andapoptosis.eng[Fen > Tıp > Cerrahi]Araştırma Makalesi10.5137/1019-5149.JTN.21417-17.2