Çavuşoğlu T.G.Darıverenli E.Vural K.Ekerbicer N.Ulman C.Ölmez E.Uysal N.2024-07-222024-07-22202002504685http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13920Objectives: Type 2 diabetes is a common metabolic disease and anxiety disorders are very common among diabetics. Buspirone is used in the treatment of anxiety, also having blood glucose-lowering effects. The aim of the study was to investigate the effects of buspirone on the glucose and lipid metabolism as well as vascular function in type 2 diabetic rats. Methods: A type 2-diabetic model was induced through a high-fat diet for eight weeks followed by the administration of low-dose streptozotocin (35 mg/kg, intraperitoneal) in rats. Buspirone was given at two different doses (1.5 mg/kg/d and 5 mg/kg/d) and combined with metformin (300 mg/kg/d). The fasting glucose and insulin levels, lipid profile were analyzed, and vascular response measured from the thoracic aorta was also evaluated. Results: Both doses of buspirone caused a significant improvement in fasting blood glucose levels. In particular, the buspirone treatment, combined with metformin, improved endothelial dysfunction and was found to be correlated with decreased nitrate/nitrite levels. Conclusions: Buspirone may be effective in the treatment of type 2 diabetes, either alone or in combination with other treatments, particularly in terms of endothelial dysfunction, inflammation and impaired blood glucose, and insulin levels. © 2020 De Gruyter. All rights reserved.EnglishAll Open Access; Gold Open Accessacetylcholineanxiolytic agentbuspironeC reactive proteincarbohydratecholesterolfatglucosehigh density lipoproteinhigh density lipoprotein cholesterolmalonaldehydemetforminnitratenitric oxidenitroprusside sodiumolanzapinephenylephrineproteinstreptozocinsuperoxide dismutasetriacylglycerolurethanvery low density lipoproteinanimal experimentanimal modelanimal tissueantidepressant activityArticlebiochemical analysisblood analysisblood vessel reactivitybody weightcardiovascular riskcircadian rhythmcontrolled studydiastolic blood pressureendothelial dysfunctionenzyme linked immunosorbent assayglucose blood levelglycemic controlheart ratehomeostasis model assessmenthyperglycemiainflammationinsulin levelinsulin resistancelipid analysislipid dietlipid fingerprintinglipid metabolismmalenon insulin dependent diabetes mellitusnonhumanoxidative stressprevalenceratsensitivity analysissystolic blood pressurethoracic aortavascular activityArticle10.1515/TJB-2019-0224