Muhammed ALTINIŞIKEylem ÇAĞILTAYFahrettin AKAYSjaak POUWELSNur DEMİR2024-07-242024-07-242020http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/24522Objective: The aim of this study is to investigate how acute hyperglycaemicchanges affect the choroid in patients with prediabetes.Material and Method: Each subject underwent a 75 g oral glucosetolerance test (OGTT) after overnight fasting. The measurementof choroidal thickness (ChT) was done with new generationspectral domain optical coherence tomography (SD-OCT).Results: Fasting Plasma Glucose (FPG) levels of the patients withonly isolated Impaired Fasting Glucose (IGT) patients are higher(all p<0.0001). Mean insulin levels were also higher in patientswith prediabetes than in healthy volunteers during the entire experiment(all p<0.0001). Changes in ChT differed between thegroups, a transient increase was observed in the mean ChT aswell as subfoveal, nasal and temporal locations at the 500 μmdistance to fovea in prediabetes individuals. While the subfovealChT difference was 1.52±4.11 μm (range, -11.00/24.00 μm)in prediabetes, -0.22±1.74 μm (range -2.00/8.00 μm) in the controlgroup at the first hour of the OGTT. A transient choroidalthickening occurred in the prediabetes group, while there was Lunochange in the healthy volunteers.Conclusion: Detecting acute hyperglycemic changes with instantmeasurements may help us to better understand the effectof the disease on ocular structures.engTHE MEASUREMENT OF THE CHOROIDAL THICKNESS DURING ORAL GLUCOSE TOLERANCE TESTS IN PREDIABETIC SUBJECTS: A SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY STUDYAraştırma Makalesi10.26650/IUITFD.2019.0095