Kahraman S.Erul E.Seyyar M.Gumusay O.Bayram E.Demirel B.C.Acar O.Aksoy S.Baytemur N.K.Sahin E.Cabuk D.Basaran G.Paydas S.Yaren A.Guven D.C.Erdogan A.P.Demirci U.Yasar A.Bayoglu İ.V.Hizal M.Gulbagci B.Paksoy N.Davarci S.E.Yilmaz F.Dogan O.Orhan S.O.Kayikcioglu E.Aytac A.Keskinkilic M.Mocan E.E.Unal O.U.Aydin E.Yucel H.Isik D.Eren O.Uluc B.O.Ozcelik M.Hacibekiroglu I.Aydiner A.Demir H.Oksuzoglu B.Cilbir E.Cubukcu E.Cetin B.Oktay E.Erol C.Okutur S.K.Yildirim N.Alkan A.Selcukbiricik F.Aksoy A.Karakas Y.Ozkanli G.Duman B.B.Aydin D.Dulgar O.Er M.M.Teker F.Yavuzsen T.Aykan M.B.Inal A.Iriagac Y.Kalkan N.O.Keser M.Sakalar T.Menekse S.Kut E.Bilgin B.Karaoglanoglu M.Sunar V.Ozdemir O.Turhal N.S.Karadurmus N.Yalcin B.Nahit Sendur M.A.2024-07-222024-07-22202314796694http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/12153Background: Ribociclib, palbociclib and abemaciclib are currently approved CDK4/6 inhibitors along with aromatase inhibitors as the first-line standard-of-care for patients with hormone receptor-positive, HER2-negative metastatic breast cancer. Methods: The authors report retrospective real-life data for 600 patients with estrogen receptor- and/or progesterone receptor-positive and HER2-negative metastatic breast cancer who were treated with ribociclib and palbociclib in combination with letrozole. Results & conclusion: The results demonstrated that the combination of palbociclib or ribociclib with letrozole has similar progression-free survival and overall survival benefit in real life for the patient group with similar clinical features. Specifically, endocrine sensitivity may be a factor to be considered in the treatment preference. © 2023 Future Medicine Ltd.EnglishAminopyridinesAntineoplastic Combined Chemotherapy ProtocolsBreast NeoplasmsFemaleHumansLetrozoleReceptor, ErbB-2Retrospective StudiesTreatment Outcomeepidermal growth factor receptor 2estrogen receptorletrozolepalbociclibprogesterone receptorribociclibaminopyridine derivativeantineoplastic agentepidermal growth factor receptor 2letrozolepalbociclibribociclibadultagedanemiaArticleclinical featurecohort analysiscontrolled studydrug dose reductiondrug efficacydrug preferencedrug withdrawalestrogen receptor-positive, HER2-negative breast cancerfebrile neutropeniafemalehormone receptor-positive, HER2-negative breast cancerhormone sensitivityhumanhypertransaminasemialiver toxicitymajor clinical studymaleneutropeniaoverall survivalprogesterone receptor positive breast cancerprogression free survivalretrospective studythrombocytopeniabreast tumorpathologytreatment outcomeArticle10.2217/fon-2022-1287