Temiz P.Akkaş G.Neşe N.Uğur Duman F.Karakaş C.Erhan Y.2024-07-222024-07-22201513000144http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16324Background/aim: To identify the role of gene products associated with apoptosis and cell cycle in the pathogenesis of thyroid follicular neoplasm. Materials and methods: Thirty follicular adenomas (FAs), 16 follicular carcinomas (FCs), and 20 adenomatous nodules (ANs) were investigated with immunohistochemical staining of p16, p21, p27, p53, Bcl-2, Bax, Bcl-xL, and cyclin D1 via a tissue microarray method. Results: Bcl-2 showed a significant difference between the benign groups (AN and FA) and the malignant group (FC). Bax was significantly higher in the FC group. p53 was lowest in the AN group and highest in the FC group with significant differences between the groups. p16 was significantly higher in the FC group than in the other groups. There was a significant difference between the AN group and neoplastic lesions in terms of p21 staining. The number of cases with positive p27 was lower in the AN group than the neoplastic groups. There was no significant difference in terms of Bcl-xL and cyclin D1. Conclusion: Cell cycle modulators, led by the Bcl-2 family, played an important role in the pathogenesis of thyroid follicular neoplasm, and p53, p16, and p21 in particular played a role in the carcinogenesis of FC. © TÜBİTAK.EnglishAll Open Access; Hybrid Gold Open AccessAdenocarcinoma, FollicularAdenomaAdultApoptosisbcl-2-Associated X ProteinCell Cycle CheckpointsCell Cycle ProteinsCyclin D1FemaleHumansHyperplasiaImmunohistochemistryMaleMiddle AgedThyroid NeoplasmsThyroid NoduleTissue Array Analysiscell cycle proteincyclin D1protein Baxprotein bcl 2protein bcl xlprotein p16protein p21protein p27protein p53cell cycle proteincyclin D1protein Baxadenomatous polypadolescentadultagedapoptosisArticlecontrolled studyfemalefollicular carcinomahumanhuman tissueimmunohistochemistrymalethyroid follicular carcinomathyroidectomytissue microarrayadenocarcinomaadenomacell cycle checkpointhyperplasiametabolismmiddle agedpathologythyroid nodulethyroid tumortissue microarrayArticle10.3906/sag-1406-48