Berdeli A.Cam F.S.2024-07-222024-07-22200900062928http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18745Angiotensin converting enzyme (ACE) plays an essential role in the renin-angiotensin system. It converts angiotensin I to angiotensin II and inactivates bradykinin and tachykinins. Numerous studies have been published investigating associations of the ACE gene I/D polymorphism with various pathophysiological conditions. We examined the prevalence of the ACE I/D polymorphism in a sample of healthy volunteers from western Turkey, including 1063 healthy Turkish controls. Analysis of the ACE I/D gene polymorphisms by polymerase chain reaction found frequencies of 16.1% for the II genotype, 47.7% for the ID genotype, and 36.2% for the DD genotype. The allele frequency was 39.9% for the I alleles and 60.1% for the D allele. This study demonstrates that the allele and genotype frequency values for the Turkish population are similar to previously published frequencies for Caucasian populations. © 2009 Springer Science+Business Media, LLC.EnglishAdultAllelesGene FrequencyGenotypeHumansINDEL MutationPeptidyl-Dipeptidase APolymorphism, GeneticTurkeyYoung Adultdipeptidyl carboxypeptidaseadultarticleCaucasiancontrolled studygene frequencygenotypehumanindel mutationnormal humanpolymerase chain reactionprevalenceprotein functionTurkey (republic)Article10.1007/s10528-009-9240-8