Örgüç S.Arkun R.2024-07-222024-07-22202010897860http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13728In the musculoskeletal system, tumor-like lesions may present similar imaging findings as bone and soft tissue tumors and can be defined as tumors on radiologic examinations. Misinterpretation of the imaging findings can lead to inappropriate clinical management of the patient. There is still some debate regarding the pathophysiology and origin of tumor-like lesions that include congenital, developmental, inflammatory, infectious, metabolic, reactive, posttraumatic, post-therapeutic changes, and some miscellaneous entities causing structural changes. Although tumor-like lesions are historically defined as non-neoplastic lesions, some of them are classified as real neoplasms. We discuss a spectrum of entities mimicking tumors of bone and soft tissues that include various non-neoplastic diseases and anatomical variants based on imaging findings. © 2020 BMJ Publishing Group. All rights reserved.EnglishAnatomic VariationBone NeoplasmsDiagnosis, DifferentialHumansMuscle NeoplasmsSoft Tissue Neoplasmsabscessaneurysmal bone cystArticlebone cystbone lesionbone tumorbrodie abscessdiagnostic imagingdifferential diagnosisepidermoid cystErdheim Chester diseasefibrous cortical defectfibrous dysplasiafibroxanthomagranulomahematomahumanhyperparathyroidismintraosseous epidermoid cystintraosseous ganglionjuxta articular bone cystLangerhans cell histiocytosisnonossifying fibromaossifying myositisosteofibrous dysplasiapriority journalsoft tissue tumorsolitary bone cystunicameral bone cystanatomical variationbone tumordifferential diagnosismuscle tumorpathologysoft tissue tumorArticle10.1055/s-0040-1721378