Ozdemir D.Baykara B.Aksu I.Kiray M.Sisman A.R.Cetin F.Dayi A.Gurpinar T.Uysal N.Arda M.N.2024-07-222024-07-22201218727972http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17762It is well known that traumatic brain injury (TBI) induces the cognitive dysfunction resulting from hippocampal damage. In the present study, we aimed to assess whether the circulating IGF-I levels are associated with cognition and hippocampal damage in 7-day-old rat pups subjected to contusion injury. Hippocampal damage was examined by cresyl violet staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. Spatial memory performance was assessed in the Morris water maze. Serum IGF-1 levels decreased in both early and late period of TBI. Decreased levels of serum IGF-1 were correlated with hippocampal neuron loss and spatial memory deficits. Circulating IGF-1 levels may be predictive of cognitive dysfunction resulted from hippocampal damage following traumatic injury in developing brain. Therapy strategies that increase circulating IGF-1 may be highly promising for preventing the unfavorable outcomes of traumatic damage in young children. © 2011 Elsevier Ireland Ltd.EnglishAnimalsBrain InjuriesCognitionCognition DisordersHippocampusInsulin-Like Growth Factor IRatsRats, WistarStatistics as Topicsomatomedin Canimal experimentanimal modelanimal tissuearticlebrain contusionbrain damagebrain developmentbrain nerve cellcognitive defectcontrolled studydentate gyrusescape behaviorhippocampuslatent periodleft hemispheremaze testmemory disordernerve cell necrosisnick end labelingnonhumanpredictive valueprefrontal cortexpriority journalprotein blood levelratright hemispherespatial memorytask performancetraumatic brain injuryArticle10.1016/j.neulet.2011.11.059