Serum level of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in acute coronary syndromes and relationship with prognosis; [Akut Koroner Sendromlarda ̇ Insl̈in Benzeri Büyüme Faktörü-I ve ̇ Insülin Benzeri Büyüme Faktörü Baǧlayici Protein-3 Düzeyleri ve Prognozla ̇ Ilişkisi]

Şekuri C.Arslan Ö.Ütük O.Bayturan Ö.Onur E.Tezcan U.K.Tavli T.2024-07-222024-07-22200413028723http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19962Objective: The aim of the present study was to examine the levels of insulin-like growth factor (IGF-I) and binding protein-3 (IGFBP-3) in acute coronary syndrome (ACS) and their relationship with prognosis. Methods: Thirty patients with ACS (22 male, 8 female) were included in our study. Patient's population included 20 patients with ST elevation myocardial infarction (STEMI) and 10 with non-ST-elevation ACS. Death, re-infarction, revascularization and malignant arrhythmia were monitored during 3 months. Study group was compared with 20 healthy subjects (Controls). Blood samples were collected in the first 24 hours and at the end of third month. Serum IGF-I and IGFBP-3 levels were determined by radioimmunoassay method. Results: We found decreased level of IGF-I only in the STEMI group (105±84 ng/ml vs. 715±150 ng/ml, p<0.0001). There were no significant differences in IGFBP-3 levels between two groups. Serum IGF-I levels were significantly increased after 3rd month in the STEMI group (356±72 ng/ml vs. 105±84 ng/ml, p=0.025). There was no relationship between IGF-I, IGFBP-3 levels and cardiovascular events occurred during 90 days of follow-up. Conclusion: These data allows to suggest that significantly decreased level of IGF-I in STEMI group of ACSs can be used as a marker of myocardial necrosis. There was no relationship between IGF-I level and cardiovascular events occurred in 90 days, so this parameter can not be used as a negative prognostic factor.TurkishCase-Control StudiesCholesterolCholesterol, HDLCholesterol, LDLFemaleHumansInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IMaleMiddle AgedMyocardial InfarctionPrognosisSeverity of Illness IndexTriglyceridesTurkeysomatomedin binding protein 3somatomedin Ccholesterolhigh density lipoprotein cholesterollow density lipoprotein cholesterolsomatomedin binding protein 3somatomedin Ctriacylglyceroladultagedarticleblood analysisclinical articlecomparative studycontrolled studydeathdisease markerfemalefollow upheart arrhythmiaheart infarctionheart muscle ischemiaheart muscle necrosisheart reinfarctionhumanmalepatient monitoringpopulation researchprognosisprotein blood levelradioimmunoassayrevascularizationST segment elevationstatistical significancebloodcase control studyheart infarctionhospitalizationmetabolismmiddle agedmortalityTurkey (republic)Serum level of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in acute coronary syndromes and relationship with prognosis; [Akut Koroner Sendromlarda ̇ Insl̈in Benzeri Büyüme Faktörü-I ve ̇ Insülin Benzeri Büyüme Faktörü Baǧlayici Protein-3 Düzeyleri ve Prognozla ̇ Ilişkisi]Article