Uyaroğlu Ö.Demiroğlu H.Topal G.Parlak Y.Gül Gümüşer F.Uluer Türköz E.Demir V.Ateş B.Ünak P.Avcıbaşı U.2025-04-102025-04-102017http://hdl.handle.net/20.500.14701/48017The aim of this study was to prepare 99mTc-Sulfamethoxazole complex and evaluate its efficiency as an infection imaging agent. The Sulfamethoxazole was labeled with 99mTc and its biological efficacy as a potential radio tracer for Staphylococcus aureus infection was investigated in bacterially infected Albino Wistar rats. The radiolabeling yield was found to be 95 ± 3.07% and remained constant at more than 93 ± 0.1% even in serum for 240 min after radiolabeling. 99mTc-Sulfamethoxazole prepared with high yield localized well in the bacterially infected muscle of the rats. 99mTc-Sulfamethoxazole may be developed as a radiopharmaceutical agent to distinguish infection from inflammation by nuclear imaging. © 2017, Springer Science+Business Media, LLC.Article10.1007/s00044-017-2009-4