Deliormanli A.M.Liu X.Rahaman M.N.2024-07-222024-07-22201415308022http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17136Borate bioactive glass has been shown to convert faster and more completely to hydroxyapatite and enhance new bone formation in vivo when compared to silicate bioactive glass (such as 45S5 and 13-93 bioactive glass). In this work, the effects of the borate glass microstructure on its conversion to hydroxyapatite (HA) in vitro and its ability to support tissue ingrowth in a rat subcutaneous implantation model were investigated. Bioactive borate glass scaffolds, designated 13-93B3, with a grid-like microstructure and pore widths of 300, 600, and 900 μm were prepared by a robocasting technique. The scaffolds were implanted subcutaneously for 4 weeks in Sprague Dawley rats. Silicate 13-93 glass scaffolds with the same microstructure were used as the control. The conversion of the scaffolds to HA was studied as a function of immersion time in a simulated body fluid. Histology and scanning electron microscopy were used to evaluate conversion of the bioactive glass implants to hydroxyapatite, as well as tissue ingrowth and blood vessel formation in the implants. The pore size of the scaffolds was found to have little effect on tissue infiltration and angiogenesis after the 4-week implantation. © The Author(s) 2012 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.EnglishAnimalsBiocompatible MaterialsBoratesGlassProstheses and ImplantsRatsRats, Sprague-DawleyTissue ScaffoldsBioactive glassBlood vesselsHydroxyapatiteMicrostructurePore sizeRatsScaffoldsScanning electron microscopySilicatesTissueBioactive glasspore sizerobocastingscaffoldsubcutaneous implantationboric acidglasshydroxyapatitesilicatetissue scaffoldDifferent pore sizesGlass scaffoldsImplantation modelsRobocastingSimulated body fluidsSprague-Dawley ratsTissue in-growthVessel formationangiogenesisanimal experimentarticlebody fluidchemical structurecontrolled studyfemalehistologyimmersionimplantationin vitro studynonhumanpriority journalratscanning electron microscopysimulationtissue growthScaffolds (biology)Article10.1177/0885328212470013