Kaya, YAral, ECoskun, TErkasap, NVar, A2024-07-182024-07-180022-4804http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/7854Background. There are many experimental studies showing that increased intraabdominal pressure (LAP) reduces liver blood flow, leading to ischemia and portal venous congestion. But, there is no study evaluating the effect of increased IAP on liver regeneration. It is well known that acute liver ischemia and portal venous congestion impair liver regeneration. We, therefore, aimed to determine the effect of increased LAP on liver regeneration in this study. Methods. Sprague-Dawley rats underwent partial hepatectomy with or without IAP of 12-14 mm Hg for 24 h or sham operation. Rats were randomly divided into six groups: two sham-operated groups, two hepatectomy groups, and two hepatectomy with increased IAP groups. Mitotic index, proliferating cell nuclear antigen (PCNA)-labeling index, and liver regeneration rate as liver regeneration parameters were studied on day 1 or on day 4 after operation. Additionally, serum aspartate transaminase (AST) level and histopathological changes in intestinal mucosa were studied. Results. Hepatectomy with/without increased UP groups had significantly higher serum AST levels than the sham-operated group on day 1. Serum AST level was found to be significantly higher in the hepatectomy with increased MY group than in the other groups on day 4. Intestinal mucosal injury was found in the hepatectomy with increased UP groups on days 1 and 4. Mitotic index and PCNA-labeling index were markedly higher in all hepatectomy with/without increased UP groups than in the sham-operated groups. However, together with liver regeneration rate, both indices were significantly less in the hepatectomy with increased UP groups than in the hepatectomy groups both on day 1 and on day 4. Conclusion. Maintenance of UP between 12 and 14 mm Hg for 24 h impaired liver regeneration after partial hepatectomy in rats. (C) 2002 Elsevier Science (USA).EnglishABDOMINAL COMPARTMENT SYNDROMECELL NUCLEAR ANTIGENINTESTINAL ISCHEMIABLOOD-FLOWBACTERIAL TRANSLOCATIONCIRRHOTIC RATSBILIARY-TRACTGUT ISCHEMIAREPERFUSIONINJURYArticle