Çökmüş F.P.Özmen E.Alkin T.Batir M.B.Çam F.S.2024-07-222024-07-22201924750573http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14656BACKGROUND: Studies on the role of microRNAs (miRNA) in anxiety disorders are limited. We aimed to determine the availability of miRNAs as biomarkers in serum and to demonstrate the changes of miRNAs expression in patients with panic disorder (PD). METHODS: Thirty-five patients with PD and 35 healthy controls (HC) were evaluated with Structured Clinical Interview for DSM Disorders-I (SCID-I) and Panic Disorder Severity Scale (PDSS). In each group miRNA expression analysis was performed in venous blood by the Real-time Polymerase Chain Reaction (RT–PCR) method for genetic evaluation. RESULTS: Compared with the HC group, eight miRNA expression levels were found different in the PD group. Five of them were upregulated and three of them were downregulated. There was no correlation between the levels of miRNA expression with PDSS total score and PDSS sub-items. However, miR-1297 and miR-4465 expression levels were significantly different between the two groups. LIMITATIONS: There are some limitations in this research. Firstly the number of samples is small. Another limitation of our study is that the presence of medical illness and continuous drug use were not excluded when PD and HC groups were selected. CONCLUSIONS: Our research is the first miRNA expression study in patients with PD which excluded psychotropic use and additional psychiatric disorders. In the PD group, miR-1297 and miR-4465 expression was upregulated than compared to the HC group. miR-1297 and miR-4465 regulate the GABAA gene regions that affect GABA A receptor subtypes that thought to play a role in the aetiology of PD. © 2018, © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.EnglishAll Open Access; Gold Open Accessbiological markercomplementary DNAGABAergic receptor affecting agentmicroRNAmicroRNA 1297microRNA 203a 3pmicroRNA 4458microRNA 4465microRNA 488 3pmicroRNA 98 5punclassified drugadultArticleclinical articlecontrolled studydown regulationDSM-IVfemalegene expression levelgenetic analysishumanmalemental diseasemental disease assessmentpanicPanic Disorder Severity Scalereal time polymerase chain reactionreceiver operating characteristicRNA isolationStructured Clinical Interview for DSM Disordersupregulationvenous bloodArticle10.1080/24750573.2018.1429844