Çavusoglu T.Erbas O.Karadeniz T.Akdemir O.Acikgoz E.Karadeniz M.Tuglu M.I.Ates U.2024-07-222024-07-22201409477349http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17018Background: One of the major concerns is a nephropathy in diabetes, which applies many different kinds of medicines. However, required level of the treatment of renal disease has not been achieved. Aim: To investigate and compare the effect of the enalapril and the exenatide on diabetic nephropathy in rats developed diabetes by streptozosin. Material and Methods: 32 male Sprague Dawley rats were divided into 4 groups: (1) Control, (2) Diabetic (DM), (3) DM+ Enalapril, and (4) DM+ exenatide groups. Then, the animals were euthanized and their blood samples were collected by cardiac puncture for blood glucose; blood urea nitrogen (BUN), creatinin, and nephrectomy were performed for histopathologic examination, and urine samples were taken on stick for proteinuria. Results: Administration of the enalapril or the exenatide in diabetic rats resulted in a significant reduction both fibronectin, induced nitric oxide synthase (i-NOS) expression in glomerular area and urine protein levels. It was shown that both of enalapril and exenatide protected the renal glomerulus more than diabetic group in the nephropathy histopathologically. Conclusion: The beneficial effects of enalapril and exenatide which reduces fibronectin, i-NOS expression and urine protein levels or increases recovery of glomerules, might be used for preventing the harmful effects of diabetic nephropathy. © 2014 Georg Thieme Verlag KG Stuttgart New York.EnglishAnimalsAntihypertensive AgentsDiabetes Mellitus, ExperimentalDiabetic NephropathiesEnalaprilGene Expression Regulation, EnzymologicHypoglycemic AgentsMaleNephronsNitric Oxide Synthase Type IIPeptidesRatsRats, Sprague-DawleyVenomscreatinineenalaprilexendin 4fibronectinglucagon like peptide 1glucoseinducible nitric oxide synthaseservierunclassified drugantidiabetic agentantihypertensive agentenalaprilexendin 4inducible nitric oxide synthaseNos2 protein, ratpeptidevenomanalytical equipmentanimal experimentanimal modelanimal tissuearticleautoanalyzerbrush bordercomparative studycontrolled studycreatinine blood leveldiabetic nephropathydilatationdissociationdrug effectglomerular structureglomerulusglucose blood levelhistopathologyimmunityimmunohistochemistryimmunoreactivityinvestigative procedureskidney parenchymakidney tubule epitheliummalenephrectomynonhumanpriority journalprotein depletionprotein determinationprotein expressionprotein urine levelproteinuriaratrenal protectiontreatment responsetubular dilatationurea nitrogen blood levelurinalysisurine dipstickanimalbiosynthesisDiabetes Mellitus, ExperimentalDiabetic Nephropathiesdrug effectsgene expression regulationmetabolismnephronpathologySprague Dawley ratArticle10.1055/s-0034-1372584