Increased vitamin D binding protein levels are associated with irritable bowel syndrome; [Artmis D vitamini baglayici protein seviyeleri Irritabl barsak sendromu ile iliskilidir]

Börekci E.Kili M.Ozan Z.Börekci H.Yildirim T.Göçmen Y.Bas H.2024-07-222024-07-22202102504685http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13185Objectives: There is no reliable and valid biomarker to identify Irritable bowel syndrome (IBS) and its subtypes. The aim of this study is to explore potential serum biomarkers that may be associated with IBS subtypes, particularly in the vitamin D pathway. Methods: The study population comprised 75 IBS patients and 79 controls. Patients divided into IBS subtypes. Routine biochemical parameters, 25-OH-vitamin D, vitamin D binding protein (VDBP) and vitamin D receptor (VDR) serum levels were compared between IBS subtypes and controls. Factors related to IBS subtypes were examined by multivariate logistic regression analysis. Results: Vitamin D levels were lower; VDBP and VDR were higher in all IBS patients than in controls (p<0.001; 0.047 and 0.029, respectively). According to logistic regression analysis, VDBP was a disease-related parameter as much as vitamin D in all IBS subtypes. C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were higher especially in diarrhea-dominant IBS (IBS-D) (p=0.041; 0.046) and vitamin B12 were significantly lower in constipation-dominant IBS (IBS-C) (p=0.001). Conclusions: Increased VDBP levels were associated with all IBS subtypes. Patients, especially in IBS-D, had higher serum levels of VDBP, CRP and ESR. Vitamin B12 deficiency, which we consider as a result of the disease, was more common in IBS-C Open Access. 2021 Elif B rekci et al. © 2021 De Gruyter. All rights reserved.EnglishAll Open Access; Gold Open Access25 hydroxyvitamin Dalanine aminotransferaseaspartate aminotransferasebiochemical markerbiological markerC reactive proteincreatininelow density lipoprotein cholesterolthyrotropinvitamin D binding proteinvitamin D receptoradultalanine aminotransferase blood levelArticleB12 deficiencybody masscholesterol blood levelcontrolled studydiagnostic test accuracy studydiarrheaerythrocyte sedimentation ratefemalegene expressionhematocrithumanhuman tissueirritable colonmajor clinical studymaleplatelet countprotein blood levelprotein expressionvitamin blood levelvitamin D deficiencyIncreased vitamin D binding protein levels are associated with irritable bowel syndrome; [Artmis D vitamini baglayici protein seviyeleri Irritabl barsak sendromu ile iliskilidir]Article10.1515/TJB-2020-0305