Inan S.Y.Aksu F.Baysal F.2024-07-222024-07-22200000142999http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20473The effects of three K+ channel blockers, 4-aminopyridine, 3,4-diaminopyridine and apamin, on scopolamine- or electroconvulsive shock-induced amnesia were investigated in mice by using a one-trial step-down passive avoidance system. Scopolamine and electroconvulsive shock reduced the retention latency of passive avoidance, which indicated the amnestic effect of these treatments. 4-Aminopyridine, 3,4-diaminopyridine and apamin injected immediately after the acquisition trial, reversed the amnestic effect of scopolamine or electroconvulsive shock in a dose-dependent manner. None of the drugs or electroconvulsive shock treatment affected the rotarod or activity cage performance of the mice. These results indicate that K+ channel blockers may improve cognitive deficits when memory is impaired by a drug or any other manipulation. Copyright (C) 2000 Elsevier Science B.V.English4-AminopyridineAmnesiaAnimalApaminAvoidance LearningElectroshockMaleMiceMuscarinic AntagonistsPotassium Channel BlockersRetention (Psychology)ScopolamineSupport, Non-U.S. Gov't3,4 diaminopyridine4 aminopyridineapaminpotassium channel blocking agentscopolamineamnesiaanimal experimentanimal modelarticlecontrolled studyelectric shockmalemousenonhumanpassive avoidancepriority journalArticle10.1016/S0014-2999(00)00736-6