Inan U.U.Öztürk F.Kaynak S.Ilker S.S.Özer E.Güler C.2024-07-222024-07-2220010721832Xhttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20461Background: Our aim was to evaluate the effect of an intraoperative single dose of retinoic acid (RA) or mitomycin C (MMC) in preventing posterior capsule opacification (PCO). Methods: Twenty-seven rabbits were divided randomly into three groups. RA (250 μg/ml) and MMC (0.04 mg/ml) were given 0.1 ml by hydrosection and 0.9 ml into the capsular bag after phacoemulsification. The third group served as a control group. Three months after intervention PCO was graded clinically. Furthermore, proliferation of lens epithelial cells was evaluated histologically. Results: Two eyes developed corneal edema in the MMC group. On clinical assessment, RA and MMC were significantly effective in preventing PCO compared with controls (P<0.005). On histological analysis, there was significantly reduced proliferative activity on posterior capsules in the treatment groups, in contrast to multi-layer cells in the control group. Conclusion: Intraoperative single-dose administration of RA and MMC significantly prevented the development of PCO in rabbit eyes. The optimal biocompatible dosage must be carefully determined by further investigation.EnglishAnimalsAntimetabolitesCataractCell DivisionEpithelial CellsIntraoperative PeriodLens Capsule, CrystallineMitomycinOphthalmic SolutionsPhacoemulsificationRabbitsRandom AllocationTretinoinacri vicsfenilefrinketaminemethylcellulosemitomycinoxybuprocainephenylephrineretinoic acidsiklomidthiopentaltropicamideanimal experimentanimal modelanimal tissuearticlecataractcell proliferationcontrolled studycornea edemadose responsedrug efficacyepithelium cellintraoperative periodlens epitheliumnonhumanphacoemulsificationpriority journalrabbitrandomizationArticle10.1007/s004170100329