Yildirim F.Amanvermez Senarslan D.Yersel S.Bayram B.Taneli F.Tetik O.2024-07-222024-07-22202203913988http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/12779Background: The objective of this study was to investigate the inflammatory effects of different oxygenator flow pattern types in patients undergoing coronary artery bypass graft surgery with cardiopulmonary bypass. Methods: We designed this randomized, single-blind, prospective study of patients with coronary artery disease. We compared the systemic inflammatory effects of oxygenators with two types of flow: axial flow and radial flow. Therefore, we divided the patients into two groups: 24 patients in the axial group and 28 patients in the radial group. IL-1, IL-6, IL-10, and TNF-α were examined for cytokine activation leading to a systemic inflammatory reaction. The samples were collected at three different time intervals: T1, T2, and T3 (T1 was taken before cardiopulmonary bypass, T2 just 1 h after CPB onset, and T3 was taken 24 h after the surgery). Results: There were no significant differences in demographic characteristics between the two groups. We observed that there were notably lower levels of humoral inflammatory response parameters (IL-1, IL-6, and TNF-α) in the radial flow oxygenator group than in the axial flow group at the specific sampling times. For IL-10, there was no significant difference for any time period. Conclusion: It might be advantageous to use a radial-flow-patterned oxygenator to limit the inflammatory response triggered by the oxygenators in cardiopulmonary bypass. © The Author(s) 2022.EnglishCardiopulmonary BypassHumansOxygenatorsProspective StudiesSingle-Blind MethodSystemic Inflammatory Response SyndromeAxial flowCardiovascular surgeryDiseasesFlow patternsanesthetic agentbiological markerC reactive proteincytokineinterleukin 1interleukin 10interleukin 6procalcitonintumor necrosis factorCardiac-surgeryCardiopulmonary bypassCoronary artery bypass graftCoronary artery diseaseFlow typeInflammatory responseOxygenator flow typeProspective studySystemic inflammatory responseTNF αadultanticoagulationartery catheterizationArticlebiochemical analysisblood samplingcardiopulmonary bypasscardiopulmonary bypass timeclinical articleclinical trialcontrolled studycoronary artery bypass graftcoronary artery diseasedata analysiselectrochemiluminescenceenzyme linked immunosorbent assayerythrocyteEuroSCOREfemalehumanhypothermiaimmunoturbidimetryinflammationleukocytemaleplatelet countrandomized controlled trialsingle blind procedurevenous bloodadverse eventoxygenatorprospective studysystemic inflammatory response syndromeRadial flowArticle10.1177/03913988221075043