Browsing by Author "Çöven F."

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    Influences of an essential oil mixture supplementation to corn versus wheat-based practical diets on growth, organ size, intestinal morphology and immune response of male and female broilers
    (2012) Bozkurt M.; Küçükyilmaz K.; Çatli A.U.; Özyildiz Z.; Çinar M.; Çabuk M.; Çöven F.
    The aim of this study was to investigate the effect of diet type, supplementation diet with an essential oil mixture (EOM), and bird gender on the growth performance, carcass yield, internal organ weight, immune response, and small intestine histology of broiler chickens. To do this, a 2×2×2 factorial arrangement was designed. The variables used were: two diet types (based on either wheat or corn), 2 feed additives (with or without EOM), and gender (male or female). EOM supplementation in the diet decreased body weight in corn-fed male birds at Days 21 and 42, but not in those fed the wheat-based diet, signifying a diet × EOM × gender interaction. Cumulative feed intake was not influenced by either the diet type or EOM. The feed conversion ratio was not affected by diet type, whereas EOM improved feed conversion ratio over the 42-day growth period. Feeding birds on wheat decreased the carcass yield while it increased relative small intestine and large intestine weight. Relative weights of liver, bursa fabricius and serum infectious bursal disease (IBD) and Newcastle disease (ND) titers were not affected by any of the variables studied. EOM supplementation and feeding birds on corn increased jejunal villus height at both 21 and 42 days of age, while bird gender showed no effect. In general, EOM positively influenced body weight gain and efficiency of feed conversion in broiler chickens. Birds receiving the corn-based diet were more efficient in converting feed to body mass as compared to those fed on the wheat-based diet. © M. Bozkurt et al., 2012.
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    Determination of the most significant serotypes and antimicrobial susceptibilities of avian pathogenic escherichia col isolates in turkey; [Bestimmung der wichtigsten serotypen und der antibiotika-resistenz von pathogenen escherichia coli isolaten beim geflügel in der türkey]
    (Verlag Eugen Ulmer, 2018) Ocak F.; Çöven F.; Ertunç E.; Eğilmez T.; Türkyilmaz S.
    The present study aimed to isolate Escherichia coli from chickens with colibacillosis, to detect the presence of important serotypes (O1, O2, O18, O78) and to examine antibiotic susceptibility profiles and resistance genes in antibiotic resistant isolates in Turkey. A total of 150 E. coli isolates collected from internal organs of broilers with colibacillosis were used in the study. Antibiotic resistance status of these isolates to 12 antimicrobial agents that belong to 7 antimicrobial families was examined by the disk diffusion method. The most important 23 resistance genes in antibiotic-resistant isolates and important APEC (Avian pathogenic E. coli) serotypes were investigated by polymerase chain reaction (PCR). While 6.7% of the isolates were found to be susceptible to all antimicrobials, 66.7% were multidrug resistant. It was determined that 150 isolates of E. coli were resistant at a rate of 73.3%, 68.7%, 63.4%, and 60.7% to amoxicillin/ampicillin, tetracycline, enrofloxacin, and trimethoprim/sulfamethoxazole, respectively. The blaTEM, blaCMY, blaSHV, blaCTX, blaOXA, tetA, tetB, qnrA, drfA1, drfA7,17 and sulII antibiotic resistance genes were detected. It was determined that 18.0% of isolates were O78, 10.0% were O2, 2.7% were O1, and 2.0% were O18. It was concluded that further epidemiological studies should be designed to investigate the virulence properties and clonal groups of APEC. This study was the first research of serotypes and antibiotic resistance genes of APEC isolates in Turkey using molecular methods. © 2019, Verlag Eugen Ulmer. All rights reserved.
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    Assessment of in-vitro cytotoxicity and in-ovo virucidal antiviral efficacy of various plant extracts and bioactive molecules
    (Veteriner Fakultesi Dergisi, 2024) Çöven F.O.; Gür S.; Uyar E.; Alsakini K.A.M.H.; Karabey F.; Çöven F.; Çaliş İ.; Nalbantsoy A.
    The viral diseases that occurred in recent years have increased the interest in non-toxic to healthy cells and naturally isolated agents to struggle with these diseases. The key intention of this research is to examine both antiviral potentials against the Infectious Bronchitis model virus (IBV) and cytotoxic activities on determined cell lines of different active ingredients and medical herbs extracts for developing new antiviral agents or drugs towards SARS-CoV-2. The antiviral potency of the samples against IBV was determined as in ovo virucidal antiviral activity in specific pathogen-free (SPF) embryonated chicken eggs (ECEs). To detect antiviral activity, the haemagglutination test was performed after 48 h of incubation for all samples. The cytotoxic activity of the samples was identified on HepG2, Caco-2, HeLa, HEK293, PANC-1, PC-3, A549, MDA-MB-231, and CCD-34Lu cell lines by the MTT protocol. Hypericum perforatum extract was found to have a dominant role in cytotoxicity and antiviral activity. In addition, while nobiletin and Sambucus nigra do not exhibit cytotoxic activity on cells, they play a significant role in antiviral activity. As a consequence of our investigation, the cytotoxic and antiviral properties of Laurus nobilis, H. perforatum, and S. nigra extracts were found remarkable and the potential of these extracts was demonstrated. © 2024, Veteriner Fakultesi Dergisi. All rights reserved.