Browsing by Author "Çakmak, S"

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    Photostimulation of osteogenic differentiation on silk scaffolds by plasma arc light source
    (SPRINGER LONDON LTD) Çakmak, AS; Çakmak, S; Vatansever, HS; Gümüsderelioglu, M
    Low-level laser therapy (LLLT) has been used for more than 30 years to heal wounds. In recent years, LLLT or photostimulation has been indicated as an effective tool for regenerative and dental medicine by using monochromatic light. The aim of this study is to indicate the usability of plasma arc light source for bone regeneration. This is why we used polychromatic light source providing effective wavelengths in the range of 590-1500 nm for cellular response and investigated photostimulation effects on osteogenic differentiation of human mesenchymal stem cells (hMSCs) seeded on 3D silk scaffolds. Cellular responses were examined by using cell culture methods in terms of proliferation, differentiation, and morphological analyses. The results showed that photostimulation with a polychromatic light source (applied for 5 min from the 3rd day after seeding up to the 28th day in 2-day intervals with 92-mW/cm(2) power from 10-cm distance to the cells) enhanced osteogenic differentiation of hMSCs according to higher alkaline phosphatase (ALP) activity, collagen and calcium content, osteogenic gene expressions, and matrix mineralization. In conclusion, we suggest that the plasma arc light source that was used here has a great potential for bone regeneration.
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    The effect of personal, familial, and environmental characteristics on acne vulgaris: a prospective, multicenter, case controlled study
    (EDIZIONI MINERVA MEDICA) Karadag, AS; Balta, I; Saricaoglu, H; Kiliç, S; Kelekçi, KH; Yildirim, M; Arica, DA; Öztürk, S; Karaman, G; Çerman, AA; Bilgili, SG; Turan, E; Demirci, MM; Uzunçakmak, TK; Güvenç, SC; Ataseven, A; Ferahbas, A; Aksoy, B; Çölgeçen, E; Ekiz, Ö; Demir, FT; Bilgiç, Ö; Çakmak, S; Uçmak, D; Özuguz, P; Konkuralp, YK; Ermertcan, AT; Gökdemir, G; Baskan, EB; Alyamaç, G; Sanli, H
    BACKGROUND: There are only a few studies about epidemiological features of acne vulgaris in the literature. The aim of this study was to analyze demographic, clinical, familial and environmental characteristics of acne, the role of diet and aggravating factors and association of these factors with acne severity. METHODS: Patients with a diagnosis of mild-moderate to severe acne were consecutively interviewed at the participating centers during the study period. RESULTS: A total of 3826 patients and 759 control patients were involved in this study. Mild acne was the most common type of acne, and most of the lesions were localized on face followed by the trunk. The severity of acne was worse in patients who had a positive family history of acne. The most common triggering factor was psychological stress. We found a positive correlation with chocolate, bread, green tea, milk, white sugar, ripe banana, ice cream, apple, orange, and red meat consumption. As we compare the acne severity according to geographical features we detected mild-moderate acne was more common in Mediterranean region and severe acne was more common in East Anatolian region. Family history positivity was more common in Aegean region and least common in Central Anatolian region. There was statistically significant relationship as we compare acne severity and dietary factors such as chocolate, dairy products such as milk, sunflower seed consumption within the geographical regions. CONCLUSIONS: This study presents the demographic and clinical characteristics of acne patients in Asian and the European parts of Turkey. We believe that this study will provide a useful overview of acne in Turkey.
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    The effects of domain satisfaction on overall life satisfaction in Türkiye
    (INDERSCIENCE ENTERPRISES LTD) Çakmak, S; Emirhan, PN
    The aim of this study is to examine the determinants of overall life satisfaction in Turkiye by using six different life domains (e.g., housing, financial standing, work conditions, the government's security policies, health, and marriage). In this way, it will be possible to drive a more efficient policy implications through domain satisfactions. Life Satisfaction Survey Micro Data Set of the Turkish Statistical Institute was used in the study during the period 2014-2017, and the determinants of overall life satisfaction are estimated simultaneously using the regressions created for the six domain satisfactions. The empirical findings of the study show that financial satisfaction and marriage satisfaction increase life satisfaction more than other domains in Turkiye.
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    Random/aligned electrospun PCL/PCL-collagen nanofibrous membranes: comparison of neural differentiation of rat AdMSCs and BMSCs
    (IOP PUBLISHING LTD) Çapkin, M; Çakmak, S; Kurt, FÖ; Gümüsderelioglu, M; Sen, BH; Türk, BT; Deliloglu-Gürhan, SI
    In this study, the aligned (A) and randomly oriented (R) polycaprolactone (PCL-A and PCL-R) and PCL/collagen (PCL/Col-A and PCL/Col-R) nanofibers were electrospun onto smooth PCL membranes (PCLMs) prepared by solvent casting. In order to investigate the effects of chemical composition and nanotopography of fibrous surfaces on proliferation and on neural differentiation of mesenchymal stem cells (MSCs), adipose and bone marrow-derived rat MSCs (AdMSCs and BMSCs) were cultivated in suitable media i.e. inducing medium containing basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF), and cell maintenance medium (CMM). BMSCs adhered and proliferated on all nanofibrous membranes more efficiently than AdMSCs. PCL/Col-A was found as the most convenient surface supporting proliferation in both cell types. Immunofluorescence staining indicated that BMSCs and AdMSCs are prone for differentiation to oligodendrocytes more than they differentiate to other neuronal cell types. PCL-A nanofibrous membranes supported differentiation of MSCs to O4(+) (an oligodendrocytes surface antigen) cells in both culture media. The intensity of immunoreactivity of O4(+) cells differentiated from BMSCs on PCL-A was highest when compared with the other groups (p < 0.001). Some BIII-T signed neural cells were investigated on PCL-A nanofibrous membranes, but the intensity of immunoreactivity was lower than that of O4(+) cells. In conclusion, this study can be evaluated to establish the cell therapy strategies in neurodegenerative disorders, which are relevant to oligodendrocyte abstinence using BMSCs or AdMSCs on aligned nanofibrous membranes.
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    MANISA ULU MOSQUE AND MADRASAH IN THE LIGHT OF NEW FINDINGS
    (E.U. Printing and Publishing House) Gürbiyik, C; Çakmak, S
    Manisa Ulu Mosque, constructed during the Principality of Saruhanogullari and stands out as one of the stunning structures of Asia Minor-Turkish architecture, constitutes a part of a large Islamic-Ottoman social complex consisting of a madrasah, a tomb, a bath, a Mevlevi lodge and fountains. The findings obtained within the scope of the restoration works initiated in 2019 in the Ulu Mosque and Madrasah have enabled us to acquire interesting data, particularly with respect to the initial construction phases of the building. One of the most important findings obtained as a result of the rasping works was figuring out that the north wall of the sanctuary was added to the structure later. It was found out that the mosque was originally constructed around a courtyard like maqsurah dome mosques specific to the early Islamic period, consisted of many carriers connected by arches and a dome in front of the mihrab, and the wall existing today in the north of the sanctuary and separating the courtyard from the sanctuary was not built during the initial construction. It was revealed that this setup was changed after a short time, most likely due to climatic conditions, and a wall was added to the north of the sanctuary. In addition, it was observed that the columns and caps in this section were also left inside the wall during the construction. Although it is known that the construction of the madrasah located in the west was completed approximately 10 years after the building of the mosque, it was controversial whether the construction of both structures was planned at one and the same time. The presence of window aperture and connecting lines between the sanctuary and the western wall of the courtyard between the madrasa and the mosque, some of which were closed later, revealed that the construction of the madrasah was decided afterwards. The research conducted out with respect to various parts of the roof within the scope of the restoration works have enabled to obtain interesting data regarding the original cover. The structure was covered with a reinforced concrete cover that looked like lead plate before the restoration works. The front part of the mihrab and the domes of the tomb were covered with lead. It was seen through the various documents and old photographs obtained regarding the structure that it was actually covered with tiles for many years. The flawed terracotta jugs of the 14th century, found in the spaces between the squinches and the dome as a result of the cleaning works carried out in this area, and the soil layer around them proved that the roof of the mosque and the madrasah was originally earth-sheltered.