Browsing by Author "Çavdar, E"

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    Should we worry about the eyes of celiac patients?
    Dogan, G; Sen, S; Çavdar, E; Mayali, H; Özyurt, BC; Kurt, E; Kasirga, E
    Purpose: In this article, we evaluate subfoveal choroidal thickness in celiac patients with respect to adherence to the gluten-free diet and nonadherence to the gluten-free diet, comparing with age and sex matched healthy controls using spectral-domain optical coherence tomography. Materials and Methods: A case-control study among 42 celiac patients and 42 healthy participants was conducted in the Department of Pediatric Gastroenterology. Celiac patients of our policlinics compliant with spectral-domain optical coherence tomography examination enrolled in the study. Celiac patients had been asked verbally about their adherence to gluten-free diet, were evaluated according to negative or positive EmA and anti-TG2 for defining adherence, and were divided into two groups (adherence to gluten-free diet and nonadherence to gluten-free diet). Results: Subfoveal choroidal thickness was thinner in EmA (+) or anti-TG2 (+) eyes than EmA(-) or anti-TG2 (-) eyes in celiac patients, but it was not statistically significant. The mean subfoveal choroidal thickness values in eyes with celiac disease, whose diagnosis time was longer than 60 months, were thinner than shorter group. Longer duration of gluten-free diet was associated with adherence difficulty and thinner choroidal thickness (r = -0.15, p = 0.34). Adherence to gluten-free diet was 88.2% for children below the age of 60 months and 57.1% for children older than 60 months. Conclusion: In conclusion, in addition to other extraintestinal manifestations of celiac disease, diagnosis time longer than 60 months in pediatric celiac patients, nonadherence to the gluten-free diet, and antibody positivity should be focused on during ophthalmologic examination and choroid measurement.
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    Evaluation of the Relationship Between Systemic Hypertension and Subfoveal Choroidal Thickness Using Optical Coherence Tomography in Pediatric Patients
    Alkan, F; Sen, S; Çavdar, E; Mayali, H; Coskun, S
    Objective: Hypertension (HT) can cause vascular and microvascular changes. There is no barrier between systemic blood and ocular region. Changes in choroidal perfusion pressure due to HT may impair retinal function and oxygenation, and subfoveal choroidal thickness (SCT) may be affected by these changes. The aim of this study was to evaluate the effect of arterial HT on SCT in children. Method: The study was performed on 102 cases (51 patients and 51 controls), prospectively. Optical coherence tomography was used for the measurement of SCT and mean values of 3 consecutive measurements were evaluated. All cases had blood pressure measurements during all day via ambulatory blood pressure monitoring. Also, both groups were evaluated for the target organ damage. Results: There were 51 cases in patient group with the average age of 14.4 +/- 2.8 years, and the rest of 51 control cases were meanly 14.5 +/- 2.8 years in age (p=0.980). SCT was measured thinner in patients with target organ damage than the cases without target organ damage (p=0.027). SCT measurements of patients and control cases were not statistically significant different (p=0.569). Especially SCT was statistically significantly thinner in cases with increased left ventricular mass, left ventricular mass index and hypertensive nephropathy (p=0.02, p=0.00, p=0.039, respectively). Conclusion: Choroidal thickness decreases in patients with HT who develop target organ damage. Therefore, close follow-up of hypertensive patients with appropriate life changes and medical treatments is important before target organ damage develops.
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    Evaluation of Subclinical Multiple Sclerosis Patients Using Pattern Visual Evoked Potentials and Visual Field Test
    Bilgin, S; Ilker, SS; Çavdar, E; Türker, I
    Objectives: The aim of this study was to evaluate subclinical multiple sclerosis (MS) patients with normal visual acuity using pattern visual evoked potentials (PVEP) test and central 30-2 threshold visual field (VF) test. Materials and Methods: A total of 60 patients, 30 of which had a definitive MS diagnosis and 30 who were healthy volunteers, were included in the study. The participants were divided into the following three groups: Group 1 -optic neuritis (+) MS patients, Group 2 -optic neuritis (-) MS patients, and Group 3 - control group. Using white on white perimetry, SITA FAST central 30-2 threshold VF tests and 1 degrees-0.3 degrees PVEP measurements were performed. MD, PSD, p100 latency (ms), p100 amplitude (mu V), and central 0-10 degrees, 0-20 degrees, 0-30 degrees, 10-20 degrees, 10-30 degrees, 20-30 degrees retina sensitivities (db) were evaluated in all groups. Results: There was a significant difference in all parameters between Group 1 and Group 3 (p<0.05). There was a significant difference in p100 latency 1 degrees-0.3 degrees, p100 amplitude 0.3 degrees, central 0-30 degrees, 10-30 degrees, 20-30 degrees between Group 2 and Group 3 (p<0.05). There was no significant difference in the parameters except for p100 amplitude 1 degrees between Group 1 and Group 2 (p>0.05). Conclusion: The evaluation of PVEP and central 30 degrees VF can be used to monitor disease prognosis in subclinical MS patients.