Browsing by Author "Çelen, I"

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    The effect on the sensitivities of PSA and PSA-age volume score of IPSS and nocturia in predicting positive prostate biopsy findings
    Üçer, O; Müezzinoglu, T; Çelen, I; Temeltas, G
    Objective: The PSA-age volume (PSA-AV) score was calculated by multiplying the age and prostate volume and then dividing the total by the prebiopsy PSA level. The aim of this study was to evaluate the effect on the sensitivities of PSA and PSA-AV score of International Prostate Symptom Score (I-PSS) and nocturia in predicting positive prostate biopsy findings. Subjects and methods: A total of 1302 biopsies data were divided into two groups according to presence/absence of nocturia. Of these biopsies, 452 biopsies data with I-PSS were also divided into three groups according to severity of I-PSS. The sensitivities, specificities, positive and negative predictive values of the PSA-AV and PSA in all the groups were calculated separately. Results: Although the sensitivities of PSA and PSA-AV were similar in the patients with nocturia (94.1% and 95.8%, respectively), the sensitivity of PSA-AV (99.2%) was higher than PSA (91.8%) in the patients without nocturia. The sensitivities of PSA in mild, moderate and severe I-PSS group were found to be 100%, 92.9% and 95%, respectively (the sensitivities of PSA-AV were 100%, 94.4% and 88.2%, respectively). While severity of I-PSS was decreasing, although sensitivity of PSA-AV increased regularly, sensitivity of PSA was variable. Conclusions: All our data shows that if we remove most of the factors which effect PSA such as age, prostate volume, prostatitis and BPH, we may increase the sensitivity of PSA for predicting positive prostate biopsy. Further PSA formulas contain of result of some tests (I-PSS, uroflowmetry or postvoiding residue urine) as well as age and prostate volume should increase the sensitivity and specificity of PSA for detecting prostate cancer. (C) 2016 Pan African Urological Surgeons' Association. Production and hosting by Elsevier B.V.
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    How affected Active Surveillance the quality of life in low-risk localized prostate cancer?
    Çelen, I; Çitgez, S; Müezzinoglu, T
    Active surveillance (AS) is emerging as an alternative approach to limit the risk of overtreatment and impairment of quality of life (QoL) in patients with low-risk localised prostate cancer. Patients with prostate cancer may be distressed by the idea of living with untreated cancer. However, most of them report high levels of QoL. We aimed to assess quality of life of the patients in AS with low-risk localised prostate cancer.
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    Assessment of PSA-Age volume score in predicting positive prostate biopsy findings in Turkey
    Uçer, O; Yücetas, U; Çelen, I; Toktas, G; Müezzinoglu, T
    Objectives: To evaluate PSA-age volume (AV) scores in predicting positive prostate biopsy findings in Turkey. Materials and Methods: PSA-AV was calculated by multiplying the patient's age by the prostate volume and dividing it by the PSA level. Sensitivities and specificities of the PSA-AV were assessed by retrospective analysis of findings from 4,717 prostate biopsies. Results: The population's average age was 63.71 +/- 7.63 years, the mean PSA level was 9.73 +/- 17.01ng/mL, the mean prostate volume was 44.46 +/- 23.88 cm(3). Of the 4,717 prostate biopsies, 1,171 biopsy specimens (24.8%) were positive for prostate cancer. A PSA-AV score of 700 had a sensitivity and specificity of 95% and 15%, respectively. These values were similar to the sensitivity and specificity for a PSA cut-off of 4ng/mL (94% and 13%, respectively). Although the sensitivity of a PSA-AV cut-off of 700 in patients over 60 years was similar to the PSA cut-off of 4ng/mL and the age-adjusted PSA, in patients < 60 years, its sensitivity was higher. While the sensitivities of a PSA-AV cut- off of 700 in patients with low prostate volume was higher than a PSA cut-off of 4ng/mL, the sensitivities of both methods with moderate prostate volumes were similar. Conclusions: Considering all the biopsies, the sensitivity and specificity of a PSA-AV of 700 for predicting positive biopsy findings were similar to a PSA of 4ng/mL. We suggest the PSA-AV cut-off of 700 should only be used in patients younger than 60 with low prostate volumes (<20cm(3)).
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    The effect of trace elements in prostate cancer
    Çelen, I; Senol, F; Müezzinoglu, T
    Prostate cancer is the sixth prevailing cancer type seen all over the world. It is also the third most common cancer type among men. The aim of this study is to investigate the effects of exposure to trace elements in prostate cancer etiology and to evaluate the latest data in literature about the clinical consequences of the deposition of trace elements in prostate tissues. There is a variety of factors in prostate cancer etiology including age, ethnogenesis, family history, androgens and hormonal factors, food and environmental exposures. Nowadays it is believed that trace elements take part in the development of prostate cancer as a result of environmental pollution and exposure to carcinogenic materials. Trace elements participate in biological systems as components of enzymes or as catalysts carrying out some chemical reactions in living cells so it is known that excessive or inadequate intakes of many trace elements lead to a variety of diseases including cancer. The methods to measure the extent of exposure to trace elements include vocational history, measurements in existing pollution and air and personal survey signs. However it is difficult to compare these results with each other as result of the measurement differences in these methods. The capability of the methods used to determine the trace elements in biological and environmental systems depends on the type of the specimen (blood, urine, hair, nail) and the preparation of the specimen for the analysis. Cumulative exposure is very important in cancer etiology. Measurements in serum and plasma indicate short term exposure whereas measurements in toenails and red blood cells indicate long term exposure. Apart from that automatic analysis methods have been developed and commercial systems providing fast and numerous data with very little contribution of the user have been produced to meet the increasing needs. There is a variety of recent studies in literature on the determination of trace elements in tissues. However it is obvious that we need studies evaluating the exposures to trace elements together with their depositions in human tissues.
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    Selenium, nickel, and calcium levels in cancerous and non-cancerous prostate tissue samples and their relation with some parameters
    Çelen, I; Müezzinoglu, T; Ataman, OY; Bakirdere, S; Korkmaz, M; Nese, N; Senol, F; Lekili, M
    In the present study, tissue samples of patients with cancerous and non-cancerous prostate were analyzed for their Se, Ni, and Ca contents. Possible relationship between Se, Ni, and Ca concentrations and some parameters including preoperative prostate-specific antigen (PSA) levels, histopathological neurovascular invasion, extra-capsular extension, seminal vesicle invasion, positive surgical margins, PSA relapse after radical prostatectomy, and total Gleason scores were obtained. Inductively coupled plasma (ICP) optical emission spectrometry and ICP-mass spectrometry instruments were used for the determination of analytes interested. All the system parameters in digestion and measurement steps were optimized to obtain efficient digestion and sensitive measurements. There was no statistically meaningful difference observed in the concentration of selenium in cancerous and benign prostatic tissues (p = 0.347) while nickel levels in cancerous tissues were observed as significantly lower than benign tissues (p < 0.001). In addition, calcium concentration in cancerous tissue samples were found to be statistically lower than those in benign tissues (p < 0.001) with mean values of 657 and 1,431 mg/kg, respectively.
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    Assessment of Proportion of Hidden Patients Having Symptoms of Overactive Bladder and Why Has It Been Hidden in Female Outpatients Admitted to Hospital
    Üçer, O; Demir, Ö; Zeren, MF; Ceylan, Y; Çelen, I; Zümrütbas, AE; Temeltas, G; Bozkurt, O; Günlüsoy, B; Çelik, Ö; Ekin, G; Mertoglu, O
    Purpose: To determine the proportion of patients with undetected symptoms of overactive bladder by using the overactive bladder-validated 8 (OAB-V8) screening questionnaire and investigate these symptoms were undetected in female patients who were hospitalized. Methods: We invited 2,250 female patients hospitalized in the Aegean region of Turkey to answer a self-administered questionnaire. The questionnaire included questions on evidence of lower urinary tract symptoms (OAB-V8), relevant medical history, and demographic data. Patients with a total OAB-V8 score >= 8 were defined as having OAB symptoms. Results: The proportion of patients with OAB symptoms in this study was 40.6%. Nearly 57% of the patients with OAB symptoms had not been previously admitted to any hospital for lower urinary tract symptoms (LUTS). The two most common reasons why women with OAB symptoms did not admit themselves to a hospital because of LUTS were as follows: I did not think I had a disease and The symptoms did not bother me, with a response rate of 74.7%. The mean OAB-V8 scores of the patients with these two responses were significantly lower than those of the other patients (P<0.001). Conclusions: This is the first study to demonstrate a significant proportion of women with undetected OAB symptoms. The main reasons the women did not admit themselves to a hospital were their unawareness of the disease and because the LUTS were not bothersome. Public awareness programs on this disease may resolve this problem.