Browsing by Author "Çelik, OK"

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    BREAST CONSERVING SURGERY AND ADJUVANT RADIOTHERAPY FOR DUCTAL CARCINOMA INSITU: EXPERIENCE OF EGE UNIVERSITY
    Bölükbasi, Y; Demirci, S; Özsaran, Z; Iscan, G; Çelik, OK; Haydaroglu, A; Aras, A
    Purpose: To evaluate the treatment results of patients diagnosed with ductal carcinoma in situ (DCIS) treated with breast conserving surgery and adjuvant radiotherapy. Materials and Methods: Between 1991 and 2006, 46 patients were treated in Ege University Faculty of Medicine for DCIS, were analyzed retrospectively. All the patients underwent breast conserving surgery and adjuvant radiotherapy. Fifty Gy was delivered to whole breast through tangential portals. Boost dose was 10 Gy and it was given by photons in 3 (% 10.7) patients and electrons in 25 (% 89.3) patients. Results: Median age was 48 (range: 16- 66). Of the patients, 45.6% (21) were diagnosed by screening mammography, the others were presented with palpable mass (50%), pain (2.2%) and discharge (2.2%). The most common tumor localization was upper outer quadrant (63%). Comedo histopathology was detected in 7 patients (15.2%). After the surgery, cosmetic evaluation was as follows: 36.8% (14) excellent, 44.8% (17) good, 10.5% (4) satisfactory and 7.9% (3) fair. After radiotherapy cosmetic evaluation was performed at least 6 months after the end of treatment. The scores were found to be excellent in 34.2% (13) patients, good in 47.4% (18), satisfactory in 10.5% (4) and fair in 7.9% (3) patients (p= 0.564). Five and ten years disease free survival and local relaps free survival were 95.3%, 92.7% and 88.2%, 90.1%, respectively. Five and ten years overall survival 100% and for distant metastases free survival, these parameters were 100% and 88.3%, respectively. Conclusion: Partial mastectomy and adjuvant radiotherapy in the treatment of DCIS provides low recurrence rates and optimal cosmesis.
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    Radiation therapy for bladder cancer
    Çelik, OK; Sert, F
    The standart of care for muscle-invasive transitional-cell carcinoma of the bladder is radical cystectomy (RC) with bilateral pelvic lymph node dissection, even though RC can be associated with significant morbidity. Organ conservation by combined-modality therapy which commonplace in contemporary oncology, with succes in cancer of breast, anus, larynx, l, imb, esophagus and prostate come into question for bladeer cancers as well. Modern bladder-sparing strategies combine maximal transuretheral resection of bladder tumor (TUR-B) followed by an induction course of concurrent radiation therapy and sensitizing chemotherapy. Aproximately _ of surviving patients maintain their bladder using combined-modality therapy with long term survival rates comparable to those of RS. Organ-sparing combined-modality therapies can be recommended for selected bladder cancer patients as a safe and proven alternative.