Browsing by Author "Çelik P."
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Item Pulmonary function parameters in patients with diabetes mellitus(2002) Özmen B.; Çelik P.; Yorgancioǧlu A.; Özmen D.; Çok G.[No abstract available]Item Unusual foreign body aspiration; [Nadir görülen bir yabanci cisim aspirasyonu](2006) Çelik P.; Kaya E.; Şakar A.; Yorgancioǧlu A.Tracheobronchial foreign body aspiration in adults is rare when compared to children. In this case report, 76 years old female patient who aspirated a screw of tracheostomy canula which was taken out by fiberoptic bronchoscopy (FOB) was presented. This case showed us that education of patients about stoma care is important. The FOB can be used safely to get foreign body from distal airways.Item Effects of latanoprost and betaxolol on cardiovascular and respiratory status of newly diagnosed glaucoma patients(2006) Erkin E.F.; Çelik P.; Kayikçioǧlu Ö.; Deveci H.M.; Şakar A.Aims: To investigate the cardiovascular and respiratory effects of topical latanoprost 0.005% and topical betaxolol 0.25% monotherapy in newly diagnosed glaucoma patients. Methods: Forty newly diagnosed glaucoma patients were enrolled in this prospective, observer-masked, randomized, parallel study. Patients received either latanoprost 0.005% or betaxolol 0.25% for a duration of 3 months. Baseline evaluation included intraocular pressure (IOP) measurement and cardiorespiratory examinations including pulse rate, systolic and diastolic blood pressure measurements and spirometry. These measurements were repeated after 3 months. Results: Both latanoprost and betaxolol reduced IOP significantly (p = 0.001). After 3 months of therapy, the mean pulse rate, systolic and diastolic blood pressure values of the betaxolol group were reduced (p = 0.027, p = 0.07 and p = 0.016, respectively). No significant changes occurred in the cardiovascular measurements of the latanoprost group (p > 0.05). There were no significant changes in any of the spirometric measurements tested for both groups (p > 0.05). Conclusion: Both latanoprost and betaxolol are safe concerning respiratory functions. Betaxolol may cause small changes in the cardiovascular system, suggesting that blood pressure and pulse rates should be checked before and in regular intervals after prescribing it for the elderly. Latanoprost seems to be a safe medication in view of absence of systemic cardiovascular and respiratory side effects. Copyright © 2006 S. Karger AG.Item Thorax perfusion CT in non-small cell lung cancer(2007) Ovali G.Y.; Sakar A.; Göktan C.; Çelik P.; Yorgancioǧlu A.; Nese N.; Pabuscu Y.Objectives: We aimed to determine the perfusion differences according to the histological type, stage, volume and prognoses in the non-small cell carcinoma by thorax perfusion CT. Materials and methods: Twenty-four non-small cell carcinoma patients were included in the study. Thorax perfusion CT was done to evaluate the tumors in terms of perfusion parameters: blood flow (BF) and time to peak (TTP) values. Results: The total blood flow of the tumor in squamous cell carcinoma was significantly higher than adenocarcinoma (p = 0.031). There was no statistical difference between the perfusion parameters and other parameters. Conclusions: Perfusion CT may help us in evaluating non-small cell carcinomas. © 2007 Elsevier Ltd. All rights reserved.Item Effect of severity of asthma on quality of life(2007) Şakar A.; Yorgancioǧlu A.; Aydemir Ö.; Sepit L.; Çelik P.This study is aimed to evaluate the health related quality of life (HRQL) in asthmatics and the probable association between HRQL and disease severity and also other demographic factors by using a generic scale, SF-36 questionnaire. One-hundred and two asthmatics were enrolled. The scores of the 8 domains of SF-36 questionnaire were evaluated according to age, gender, status of education and compared with the severity of asthma. The mean age of 84 (83%) female and 18 (17%) male patients was 42.86 ± 11.15. Fifty-two of them was well educated (51%) and 50 was poorly educated (49%). Atopy ratio was 81%. Mild intermittent, mild persistent and moderate-severe persistent groups were 27 (26%), 46 (45%) and 29 (29%) respectively. Female gender were worse in physical functioning (p= 0.000), physical role difficulties (p= 0.0049), vitality (p= 0.045) and social functioning (p= 0.025). Poorly educated group were worse in physical functioning (p= 0.001), physical role difficulties (p= 0.039), vitality (p= 0.045), emotional role difficulties (p= 0.046), general health (p= 0.030) and mental health (p= 0.044). Mental health was worse in the presence of atopy (p= 0.035). Physical functioning was better in mild intermittent group than moderate and severe persistent group (p= 0.024). General health was better in mild intermittent group than mild persistent group (p= 0.018), moderate and severe persistent group (p= 0.015). Vitality and emotional role difficulties was better in mild intermittent than mild persistent group (p= 0.042, p= 0.007). The HRQL scores and severity of asthma is well correlated like other objective parameters. So one of the primary goals in management of asthma should also improve QOL as well as functional parameters.Item Assessment of performance of "amplified Mycobacterium tuberculosis direct test" in pulmonary and extrapulmonary specimens; [Akci̇ǧer ve akci̇ǧer dişi örneklerde "ampli̇fi̇ye Mycobacterium tuberculosis di̇rek test" i̇n güveni̇li̇rli̇ǧi̇ni̇n deǧerlendi̇ri̇lmesi̇](2007) Sürücüoǧlu S.; Özkütük N.; Gazi H.; Çelik P.Since rapid diagnosis is critical in control of tuberculosis, nucleic acid amplification techniques have been widely used. The purpose of the present study was to assess the performance of Amplified Mycobacterium tuberculosis Direct Test (Amplified MTD Test, Gen-Probe) for the diagnosis of pulmonary and extrapulmonary tuberculosis in our laboratory. A total of 267 specimens (170 pulmonary and 97 extrapulmonary) were tested in the Clinical Mycobacteriology Laboratory of Manisa (a province located in Aegean part of Turkey) University Hospital from September 2001 to March 2005. When Amplified MTD (AMTD) test results were compared to the culture results taken as the gold standard, the sensitivity, specificity, positive and negative predictive values (PPV, NPV) for pulmonary specimens were found to be 84%, 96%, 73%, and 98%, respectively. When AMTD test positive, culture negative discrepant results were evaluated against the clinical history of the patients, these rates were detected as; 88%, 100%, 100%, and 98%, respectively. For 97 extrapulmonary specimens, sensitivity, specificity, PPV and NPV of AMTD test were 60%, 100%, 100%, and 98%, respectively. In conclusion, the results of the AMTD assay were reliable for the rapid diagnosis of pulmonary tuberculosis; if the results were evaluated together with the clinical status of patients, the performance of the test would be increased. However, even though the culture positive extrapulmonary specimens were sparse in our study (5%), the sensitivity of the AMTD test in extrapulmonary specimens was found less than that in pulmonary specimens. Therefore it is thought that AMTD test results should be evaluated carefully for the diagnosis of extrapulmonary tuberculosis.Item Sensitivity of cough with capsaicin in smokers; [Sigara içenlerde kapsaisin ile öksürük duyarliliǧi](2008) Yildirim Ç.A.; Çelik P.; Havlucu Y.; Coşkun E.; Yorgancioǧlu A.; Şakar A.; Dinç G.In this study, effect of long term smoking on sensitivity of cough reflex was investigated. Healthy, current smoker male and female was evaluated by capsaicin cough challenge test and they were compared with healthy, non-smoker persons with similar age and gender, prospectively. In current smokers, there were 50 male and 39 female, in non-smoker control group, there were 20 male and 21 female. Mean and log C5 dosage in current smoker and non-smoker groups and mean and log C5 dosage in current smoker according to gender were calculated by using Mann-Whitney U-test. Results of capsaicin cough challenge test in current and non-smoker groups were evaluated by using Pearson Chi-Square test and Fisher's Exact test. In current smokers comparison of results of capsaicin cough challenge test with smoking history (age with first smoking, duration, pocket year and smoking per day) was evaluated by using Mann-Whitney U-test. Mean C5 and mean log C5 dosage were found decreased in current smokers when they were compared to control group (p< 0.00). In current smoker group mean C5 and mean log C5 dosage were found decreased in male (p< 0.002). When the results of capsaicin cough challenge test were compared between current smoker and control groups, sensitivity of cough reflex in concentration with 0.49, 0.98, 1.95, 3.9, 7.8, 15.6 μM was significantly decreased in current smoker group. Also there was a significant correlation between concentration with 0.98, 1.95, 3.9, 7.8, 15.6, 31.2 μM, and duration of smoking and pocket year of smoking. Also there was a correlation between concentration with 15.6, 31.2, 62.5, 125 μM and smoking per day. This results were correlated with hypothesis about inhibition of C-fibers with nicotin or decrease of C-fibers' sensitivity due to induction of neuropeptide wasting.Item Beliefs and attitudes of physicians dealing with cancer patients about quality of life: A comparative study; [Kanser hastalanyla çalişan hekimlerin yaşam kalitesine yönelik inang ve tutumlari: Karsy̧ilaştirmali bir çalişma](2009) Aydemir O.; Çelik P.; Müezzinoǧlu T.Objective: This study was designed to determine the beliefs and attitudes of physicians dealing with cancer patients about quality of life. Materials and methods: For determining the beliefs and attitudes of physicians about quality of life, a 32-item questionnaire was developed, inspired by the questionnaire developed by Bezjak et al. Two diverse specialties of physicians were enrolled, including 44 urologists, and 73 chest physicians. Results: It was found that all physicians had positive beliefs about quality of life, but they mainly relied on their own clinical experience instead of scales. When the two groups were compared, chest physicians seemed to accord more importance to prolong the patients' survival and to biological parameters in choosing the treatment than did urologists. Conclusion: All physicians dealing with cancer care have positive attitudes towards quality of life assessments. Chest physicians weight quality of life as a lowrank issue compared to urologists in the care of cancer patients. This seems to be due to high mortality rates of lung cancer.Item Celal bayar üniversitesi saǧlik grubu öǧ rencilerinde sigara ve astim prevalansi(2009) Göktalay T.; Özyurt B.C.; Çelik P.[No abstract available]Item The effect of nicotine among active, passive smoker health personnel; [Saǧlik çalişanlarinda, aktif ve pasif sigara i̇çicilerde nikotin etkilenim düzeyleri](2009) Temel O.; Coşkun A.Ş.; Gök Ş.; Çelik P.; Yorgancioǧlu A.Objective: It is aimed to evaluate the effect of environmental tobacco smoke among active and passive smoker and non-smoker health staff. Material and Method: 209 volunteers were included; age, gender, occupation and smoking habits were recorded. Exhaled air carbon monoxide (CO), urinary cotinine levels and Fagerström Nicotine Tolerance Questionnaire were performed. Results: 106 (55%) of 117 active, 66 (32%) passive smokers and 26 (13%) non-smokers were male and the mean age was 30.3 ± 6.6 (18-55). 56 (27%), 33 (16%), 80 (38%), and 40 (19%) were doctors, nurses, assistant staff and officers respectively. Mean CO level was higher in active smokers (18 ppm) than passive smokers (1.9 ppm) and non-smokers (1.5 ppm) (p=0.001). Mean urinary cotinine level was higher in active smokers (949.5 ng/ml), than passive smokers (11.3 ng/ml) and non-smokers (0.00 ng/ml) (p=0.000). Nicotine consumption in active smokers was positively and significantly related with CO, urine cotinine levels and nicotine dependency (<0.05). Conclusion: It is concluded that environmental tobacco smoke has been found to be very high in hospitals and smoke-free hospital programs should ibe started immediately.Item A case of bilateral tuberculosis with a presenting symptom of massive haemoptysis; [Masif hemoptizi ile bulgu veren bilateral tüberküloz olgusu](2009) Özgen A.; Çelik P.; Gücü A.; Konyar I.; Coşkun A.S.; Götan C.; Yongancioǧlu A.Haemoptysis may be observed in one third of patients with pulmonary tuberculosis at any time during their disease. Tuberculosis may present with atypical radiological findings in patients with underlying diseases such as Diabetes Mellitus (DM). We presented a 58-year-old male with DM who haemorrhaged from the right bronchial artery although having a radiological lesion in the left lung. He had a glassful of haemoptysis in a single episode lasting two days. Chest computarized tomography (CT) showed a consolidation partially forming a massive lesion in the left upper lobe. Bronchoscopy revealed a haemorrhagic residue in the right main bronchus and a blood clot in the left upper lobe. After aspiration a major hemorrhage was observed and bronchial arterial embolization (BAE) was performed to the right bronchial artery where extravasion of the contrast agent was determined. However,in the follow-up, as the findings of BAE were not consistent with the bronchoscopic and radiological findings, a CT angiography was performed for the evaluation of the vascular structures. No vascular pathology was determined although there were acinary infiltrations in both lungs. Also, the mycobacterial culture of the sputum was positive. Radiological, bronchoscopic and angiographic findings may not always correlate in patients with haemoptysis. Heamoptysis may result from different causes in pulmonary tuberculosis and bronchial arterial system is usually the source.Item Occupational asthma in welders and painters(Ankara University, 2010) Temel O.; Şakar Coşkun A.; Yaman N.; Sarioǧlu N.; Alkaç Ç.; Konyar I.; Özgen Alpaydin A.; Çelik P.; Cengiz Özyurt B.; Keskin E.; Yorgancioǧlu A.We aimed to investigate the frequency of occupational asthma (OA) and the factors associated with OA development in a bicycle factory, subsequently after the diagnosis of OA in three workers at the same department. Forty one welders, 23 painters and 46 controls (office workers), a total number of 110 cases were included in the study. Turkish Thoracic Society Occupational and Environmental Diseases Evaluation Questionnaire and physical examination, chest-X ray, pulmonary function tests were performed as needed. Peak expiratory flow (PEF) follow-up was done in welders and painters. Cases having symptoms related with work and ≥ 20% PEF variability were diagnosed as OA. Wheezing were more frequent in welders and painters than the control group, although there wasn't a statisticall significance. Dyspnea, cough and sputum production were more frequent in welders and painters with respect to controls (p< 0.05). Nine (22%) welder, 4 (18%) painter were diagnosed as OA. Working duration of welders and painters with OA (72, 156 months, respectively) were longer than the welders and painters without OA (45, 76 months, respectively), but it did not have any statistically significance. We suggest that working in welding and painting departments may cause respiratory symptoms and OA.Item Relationship of systemic antiinflammatory markers and functional parameters in chronic obstructive pulmonary disease; [Kronik obstrüktif akciǧer hastalıǧında fonksiyonel paramatrelerle sistemik antiinflamatuar belirteçlerin ilişkisi](AVES, 2011) Satar S.; Alpaydin A.Ö.; Var A.; Coşkun A.Ş.; Çelik P.; Yorgancioǧlu A.Objective: Airway inflammation and oxidative stress biomarkers increase in chronic obstructive pulmonary disease (COPD) and this is thought to be related to faster decrease in lung functions. Systemic markers of oxidative stress include nitric oxide (NO) and malonyl dialdehyde (MDA), while antioxidant markers are erythrocyte superoxide dismutase (SOD) and gluthathionperoxidase (GSH-Px). We investigated the relationship between levels of systemic oxidative/antioxidant markers and functional parameters. Material and Method: Fifty-one COPD patients without any systemic inflammation were included in the study. Pulmonary function test parameters were evaluated. 6-minute walk test (6MWT) and dyspnea severity were recorded. Twelve healthy persons in a control group were also included in the study. Venous blood specimens of the patients and the control group were collected and serum NO, MDA and erythrocyte SOD, GSHPx levels were measured. Results: Mean age of the patients were 62.94±10.56 years. When the control group and COPD patients were compared; MDA (p<0.001), NO (p=0.012) and GSH-Px (p=0.012) were significantly higher in the control group than COPD patients. However, when the age factor was controlled, only MDA(p=0.017) was found higher in the control group. As forced expiratory volume in 1st second (FEV1) decreased; NO, SOD, MDA and GSH-Px increased, although there was no statistical significance. Like FEV1, 6MWT and dyspnea severity by VAS did not show any statistical significance with the parameters investigated. Conclusion: From the results, we could not observe the reflections of oxidant/antioxidant imbalance on functional parameters in COPD. This may be due to incomplete systemic response to local disorders as well as the attempts of antioxidant systems to maintain an equilibrium resembling that in healthy individuals.Item Validity and reliability of "asthma quality of life questionnaire" in a sample of Turkish adult asthmatic patients; ["Asthma quality of life questionnaire" yaşam kalitesi anketinin erişkin astımlı Türk hasta örneǧinde geçerliliǧi ve güvenilirliǧi](Ankara University, 2011) Özgen Alpaydin A.; Yorgancioǧlu A.; Yilmaz O.; Bora M.; Göktalay T.; Çelik P.; Yüksel H.We aimed to investigate the validity and reliability and of "Asthma Quality of Life Questionnaire (AQLQ)" in Turkish adult asthmatic patients. New or previously diagnosed [according to Global Initative for Asthma (GINA) 2008] symptomatic 118 consecutive stable asthmatic patients between 18 and 55 years old were included. Asthma severity was determined and Turkish adaptation of the AQLQ was administered. Lara asthma symptom scales (LASS), pulmonary function tests, Turkish adaptation of Medical Outcomes Survey Short Form-36 (SF-36) were evaluated. All assessments were done twice at recruitment and after 10 weeks. During this period patients were allowed to make modifications on their medication when necessary. Among the recruited 118 patients 95 were female and 14 were lost in the follow-up. Sixty-two percentages of the patients had mild and 38% moderate asthma. The internal consistency of AQLQ was high (Cronbach's alpha 0.81-0.87) and item-total score correlations were ranging from 0.75-0.89. The cross-sectional and longitudinal correlations between AQLQ total and domain scores and SF36 domain scores were in a range of little or fair degree (r= 0.241-0.626, p< 0.005). Total AQLQ scores were observed significantly different according to disease severity and LASS both in the first (p< 0.001, both) and 10 weeks follow-up visits (p= 0.006, p< 0.001 respectively). A statistical significant change was observed in AQLQ symptom score as in total LASS changed (p< 0.001, both) in the follow-up. Our results demonstrated that Turkish version of AQLQ is feasible, reliable, valid and sensitive to changes in adult asthmatics.Item Level of smoking of 3rd and 4th grade students studying health and related factors: Follow-up study; [Saǧlık eǧitimi alan 3 ve 4. sınıf öǧrencilerinde sigara kullanımı ve etkileyen faktörler: Izlem araştırması](Ankara University, 2011) Göktalay T.; Cengiz Özyurt B.; Şakar Coşkun A.; Çelik P.The levels of smoking of 1st and 2nd year students at Faculty of Medicine and Manisa School of Health at Celal Bayar University were investigated in 2006-2007. This study is carried out in order to see if there is a change in the same students' level of smoking while they are in 3rd and 4th year. In addition, the study aimed to examine the factors affecting the level of use and attitudes towards the law effectuated in July 19, 2009. This is a follow-up study with 80.42% return rate. A 26-item structured questionnaire was administered. The participants filled out the questionnaires under supervision of the researchers in their classrooms. The University Institutional Review Board approved the study. The total of participants (263) of the follow-up study included 189 female and 74 male. The rate of experimenting with smoking was 49% with the mean age of 15.7 (SD= 4.01 years). The mean age of experimenting with smoking was the earliest on male students studying at faculty of medicine. The level of smoking was found to be the most on females, studying at faculty of medicine and staying at the dormitory, with smoking parents (p< 0.05). The most important reason to begin smoking was curiosity (55.2%) while bad breath and yellowing of teeth were the reasons to quit (91.7%). 83.3% of the students thought that the law will be effective on quit smoking. The level of both experimenting and use of smoking has been increased over time. It is suggested that medical students' awareness about the danger of smoking should be raised at earlier grades. In addition, lectures should be offered to students at School of Health and they should be encouraged to unite in order to fight with smoking.Item Serum and pleural fluid N-Terminal-Pro-B-Type natriuretic peptide concentrations in the differential diagnosis of pleural effusions; [Plevral efüzyonların ayırıcı tanısında serum ve plevral sıvı n-terminal-pro-B-tip natriüretik peptid konsantrasyonunun yeri](Ankara University, 2011) Yorgancioǧlu A.; Özgen Alpaydin A.; Yaman N.; Taneli F.; Bayturan O.; Şakar Coşkun A.; Çelik P.Currently, new biomarkers like N-Terminal-Pro-B-Type natriuretic peptide (NT-proBNP) have been used in the differential diagnosis of pleural effusions. In our study, we aimed to investigate the diagnostic value of NT-proBNP, especially in cardiac originated pleural effusions. Forty-five patients with pleural effusions were included in the study. NT-proBNP levels and biochemical markers involved in the Light's criteria were analyzed in pleural fluid and serums of the patients. Pleural fluid culture, AFB smear, cytology were performed where they were indicated according to the clinical evaluation. In patients, to whom cardiac pathology was considered to be; cardiological evaluation and echocardiography were also done. Thirtyeight pleural effusions were exudative and, 7 were transudative according to the Light's criteria. Final diagnosis were malignant effusion in 13, infection (tuberculosis/pneumonia) in 10, congestive heart failure in 21, and other conditions related with pleural effusion in 1 of the patients. Median (25th to 75th percentiles) NT-proBNP levels of serum and pleural fluid due to congestive heart failure (CHF) were 4747 pg/mL (931-15754) and 4827 pg/mL (1290-12.430) while median NTproBNP levels of serum and pleural fluid related with non-cardiac reasons were 183 pg/mL (138-444) and 245 pg/mL (187-556) respectively. NT-proBNP levels of serum and pleural fluid were significantly high in CHF (p< 0.001 for both). When four groups were compared serum and pleural fluid NT-proBNP levels were highest in the CHF group which was followed by malignancy, infection and others (p< 0.001 for both). Fourteen of 21 patients who were accepted to have congestive heart failure as the final diagnosis by a cardiological evaluation had an exudative pleural fluid according to the Light's criteria. Serum and pleural fluid NT-proBNP levels were higher in transudates and this reached statistically significance for pleural fluid (p= 0.009). We suggest that measurement of pleural fluid NT-proBNP is a smart approach and pleural fluid NTproBNP can reflect cardiac origin of effusions better than serum NT-proBNP and Light's criteria.Item Investigation of bacterial etiology with conventional and multiplex pcr methods in adult patients with community-acquired pneumonia; [Toplum kökenli pnömonisi olan eriǧkin hastalarda konvansiyonel ve multipleks pcr yöntemleriyle bakteriyel etiyolojinin araştirilmas](2012) Kurutepe S.; Ecemiş T.; Özgen A.; Blçmen C.; Çelik P.; Özkan S.A.; Sürücüoǧlu S.Community-acquired pneumonia (CAP) is still a serious life-threatening disease, in which the etiologic agent cannot be identified in more than 50% of patients despite advanced diagnostic methods. The most commonly used methods in the determination of CAP etiology are culture and serological tests. Since early and accurate therapy reduces the mortality in CAP cases, rapid and reliable diagnostic methods are needed. The aim of this study was to determine the bacterial etiology in adult patients with CAP by implementing multiplex polymerase chain reaction/reverse line blot hybridization (M-PCR/RLBH) assay combined with conventional methods. A total of 128 cases (94 were male; age range: 19-81 years, mean age: 58) who were admitted to our hospital and clinically diagnosed as CAP between November 2008 - November 2010, were included in the study. Respiratory samples (sputum and/or broncho-alveolar lavage) obtained from patients were searched by M-PCR/RLBH method (Gen ID®, Autoimmun Diagnostika GmbH, Germany) in terms of the presence of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Mycoplasma pneumoniae. Chlamydia pneumoniae and Legionella pneumophila nucleic acids. The samples were simultaneously inoculated onto 5% sheep blood agar, chocolate agar, haemophilus isolation agar, buffered charcoal yeast extract-selective agar and EMB agar media for cultivation. Serum samples obtained from the cases were tested for IgM and IgG antibodies against C.pneumoniae by microimmunofluorescence (Focus Diagnostic, USA) and against L.pneumophila and M.pneumoniae by indirect immunofluorescence (Euroimmun, Germany) methods. The bacterial etiology was identified in 59 (46.1%) of 128 patients with CAP and a total of 73 pathogens were detected. The leading organism was S.pneumoniae (n= 32, 25%), followed by H.influenzae and M.pneumoniae (n= 9, 7%), gram-negative bacilli (n= 10, 7.8%), M.catarrhalis (n= 6,4.7%), C.pneumoniae (n= 4, 3.2%), L.pneumophila (n= 2, 1.6%) and Staphylococcus aureus (n= 1, 1.4%). Infection with atypical pathogens were detected in 15 (11.7%), and mixed infections in 14 (10.9%) patients. The detection rate of microorganisms (S.pneumoniae, H.influenzae, M.catarrhalis, C.pneumoniae, L.pneumophilia, M.pneumoniae) searched by M-PCR/RLBH method was 41.4% (53/128), while those microorganisms were detected in 23.4% (30/128) of the patients by conventional methods, representing a significant difference (p< 0.05). It was concluded that M-PCR/RLBH method supplemented the determination of bacterial etiology in CAP ca-ses by increasing the rate of detection from 23.4% to 41.4%. The results indicated that empirical treatment of CAP should primarily include antibiotics against S.pneumoniae, M.pneumoniae and H.influenzae in our region.Item Putative bronchopulmonary flagellated protozoa in immunosuppressed patients(Hindawi Publishing Corporation, 2014) Kilimcioglu A.A.; Havlucu Y.; Girginkardesler N.; Çelik P.; Yereli K.; Özbilgin A.Flagellated protozoa that cause bronchopulmonary symptoms in humans are commonly neglected. These protozoal forms which were presumed to be "flagellated protozoa" have been previously identified in immunosuppressed patients in a number of studies, but have not been certainly classified so far. Since no human cases of bronchopulmonary flagellated protozoa were reported from Turkey, we aimed to investigate these putative protozoa in immunosuppressed patients who are particularly at risk of infectious diseases. Bronchoalveolar lavage fluid samples of 110 immunosuppressed adult patients who were admitted to the Department of Chest Diseases, Hafsa Sultan Hospital of Celal Bayar University, Manisa, Turkey, were examined in terms of parasites by light microscopy. Flagellated protozoal forms were detected in nine (8.2%) of 110 cases. Metronidazole (500 mg b.i.d. for 30 days) was given to all positive cases and a second bronchoscopy was performed at the end of the treatment, which revealed no parasites. In conclusion, immunosuppressed patients with bronchopulmonary symptoms should attentively be examined with regard to flagellated protozoa which can easily be misidentified as epithelial cells. © 2014 Ali Ahmet Kilimcioglu et al.Item Patient and physician delay in the diagnosis and treatment of non-small cell lung cancer in Turkey(Elsevier Ltd, 2015) Yurdakul A.S.; Kocatürk C.; Bayiz H.; Gürsoy S.; Bircan A.; Özcan A.; Akkoçlu A.; Uluorman F.; Çelik P.; Köksal D.; Ulubaş B.; Sercan E.; Özbudak T.; Göksel T.; Önalan T.; Yamansavci E.; Türk F.; Yuncu G.; Çopuraslan T.; Mardal T.; Tuncay E.; Karamustafaoğlu A.; Yildiz P.; Seçik F.; Kaplan M.; Çağlar E.; Ortaköylü M.; Önal M.; Turna A.; Hekimoğlu E.; Dalar L.; Altin S.; Gülhan M.; Akpinar E.; Savas T.; Firat N.; Çamsari G.; Özkan G.; Çetinkaya E.; Kamiloğlu E.; Çelik B.; havlucu Y.Aim: The early diagnosis and treatment of lung cancer are important for the prognosis of patients with lung cancer. This study was undertaken to investigate patient and doctor delays in the diagnosis and treatment of NSCLC and the factors affecting these delays. Materials and methods: A total of 1016 patients, including 926 (91.1%) males and 90 (8.9%) females with a mean age of 61.5. ±. 10.1 years, were enrolled prospectively in this study between May 2010 and May 2011 from 17 sites in various Turkish provinces. Results: The patient delay was found to be 49.9. ±. 96.9 days, doctor delay was found to be 87.7. ±. 99.6 days, and total delay was found to be 131.3. ±. 135.2 days. The referral delay was found to be 61.6. ±. 127.2 days, diagnostic delay was found to be 20.4. ±. 44.5 days, and treatment delay was found to be 24.4. ±. 54.9 days. When the major factors responsible for these delays were examined, patient delay was found to be more frequent in workers, while referral delay was found to be more frequent in patients living in villages (. p<. 0.05). We determined that referral delay, doctor delay, and total delay increased as the number of doctors who were consulted by patients increased (. p<. 0.05). Additionally, we determined that diagnostic and treatment delays were more frequent at the early tumour stages in NSCLC patients (. p<. 0.05). Discussion: The extended length of patient delay underscores the necessity of educating people about lung cancer. To decrease doctor delay, education is a crucial first step. Additionally, to further reduce the diagnostic and treatment delays of chest specialists, multidisciplinary management and algorithms must be used regularly. © 2015 Elsevier Ltd.Item Comparison of generic and lung cancer-specific quality of life instruments for predictive ability of survival in patients with advanced lung cancer(SpringerOpen, 2016) Eser S.; Göksel T.; Erbaycu A.E.; Baydur H.; Başarık B.; Yanık A.Ö.; Gürsul K.K.; Çelik P.; Ediz E.Ç.; Hatipoğlu O.; Yayla B.A.; Başer S.; Eser E.Background: Our purpose is to examine the relationship of Health related quality of life measured by EORTC QLQc30, QLQ-LC13; FACT-L, LCSS, Eq5D) with survival in advanced lung cancer patients. A total of 299 Lung Cancer (LC) patients were, included in this national multicenter Project entitled of “the LC Quality of Life Project (AKAYAK). Baseline scores were analyzed by using Cox’s proportional hazard regression to identify factors that influenced survival. Univariate and multivariate models were run for each of the scales included in the study. Results: Mean and median survival were 12.5 and 8.0 months respectively. Clinical stage (as TNM), comorbidity; symptom scales of fatigue, insomnia, appetit loss and constipation were associated with survival after adjustment for age and sex. Global, physical and role functioning scales of QLQc30; physical and functional scales of LCS and TOI of the FACT-L was also associated with survival. Mobility and Usual activities dimensions of the Eq5D; Physical functioning and the constipation symptom scale of the QLQ-c30; and LCS and TOI scores of the FACT-L remained statistically significant after adjustment. LC13 and LCSS scales were not predictors of survival. Conclusions: HRQOL serves as an additional predictive factor for survival that supplements traditional clinical factors. Besides the strong predictive ability of ECOG on survival, FACT-L and the Eq5D are the most promising HRQOL instruments for this purpose. © 2016, The Author(s).