Browsing by Author "Çetin M."
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Item Coronary artery-pulmonary artery fistula detected by transthoracic echocardiography: Case report; [Transtorasik ekokardiyografi ile saptanan koroner arter ile pulmoner arter arasindaki fistül](2012) Çetin M.; Yildirimer M.; Evrengül H.; Özen S.; Genç B.; Coşkun Ş.Coronary artery fistulas are direct connections, devoid of a capillary system, between any coronary arteries and 4 chambers of the heart, superior vena cava, pulmonary artery, or pulmonary veins. Although definitive consensus has not been reached regarding treatment approaches, it has usually been reported that symptom-free small fistulas have a benign course and may be followed clinically and they should be closed in patients with symptomatic fistulas or related complications. Here, we presented a case of asymptomatic fistula between proxymal left descendant coronary artery and main pulmonary artery, that has been spotted by transthoracic echocardioghraphy. Copyright © 2012 by Türkiye Klinikleri.Item Is renal and urologic findings associated with costello syndrome?: Case report; [Renal ve ürolojik bulgular costello sendromu ile ilişkili midir?](2013) Özunan Akil I.; Evrengül H.; Çetin M.; Taneli C.Costello syndrome is a rare congenital disorder affecting multiple organ systems which is inherited in a autosomal dominant manner. It is a Ras/mitogen activated protein kinase (MAPK) pathway syndrome resulting from HRAS mutations. HRAS mutations are responsible for cell pro liferation, motility, apopitosis and cell aging in eukaryotes.The phenotypic characteristics of Costello syndrome are atypical signs of face, wide mouth, thick lips loose, soft skin, deep lines on the hands and soles of the feet, kyphoscoliosis, cervical kyphosis, thick curly hair, nasal fibroma, hyperker atosis, hyperpigmentation, and also there are skeletal and orthopedic problems. Which is similar to the findings resulting from this path disregulation. Cardio fascia cutaneous syndrome and Noonan syndrome and the differential diagnosis should be made. Diagnosis is based on genetic testing in 80 90% of the cases whereas lO% are diagnosed clinically. In this report, a case presented who has got phenotypic characteristics of Costello syndrome with coarse facial appearance, eccentricity root of the nose, the palate dome, large lips, large mouth, and hypertrophic cardiomyopathy with the renal and urological anomaly presented.. Copyright © 2013 by Türkiye Klinikleri.Item Exercise test results of children with family history of hypertension; [Ailede Hipertansiyon Öyküsü Olan Çocuklarin Egzersiz Testi Yanitlari](2013) Yilmaz M.; Pirim U.; Çetin M.; Kiremitçi S.; Coşkun S.Objective: Early detection of high blood pressure in children with family history of hypertension that can not be determined during rest, is important for early treatment and prevention of complications. Exercise test is a noninvasive and inexpensive method that can detect the increases in blood pressure due to exercise. Therefore, the aim of this study is to determine the differences in blood pressure response to exercise test between children with family history of hypertension and children without a risk factor and to evaluate the exercise recommendation in the light of these findings. Material and Methods: This study enrolled 60 normotensive aged 8-16 years. Thirty children with family history of hypertension formed the disease group while thirty without family history formed the control group. Echocardiography, resting blood pressure measurement and exercise test were performed. Results: Mean ages of the children in disease and control groups were 12.0±2.8 years and 11.7±1.8 years, respectively (p=0.58; CI:-0.88-1.55). Resting systolic blood pressure was significantly higher in the disease group compared to the control group (99.5±6.7 mmHg and 95.3 ± 8.0, mmHg respectively; p=0.03; CI=0.38-8.02). Mean diastolic blood pressures were not different among the groups (p=0.53; CI=-1.51-2.91). Maximal heart rate during exercise test was significantly higher in the disease group compared to the control group (181.5±20.3/min and 170.4±22.7/min, respectively; p=0.05; CI=0.01-22.3). Mean maximal systolic and diastolic blood pressures during exercise test children in disease and control groups were 147.8 ± 18.5 mmHg, 80.7±12.2 mmHg and 151.5±20.4 mmHg, 79.4±16.1 mmHg respectively. Blood pressures during exercise test were not significantly different between the groups (p= 0.47; p=0.72). Conclusion: The results of this study demonsrate that systolic and diastolic blood pressure responses of the normotensive children with and without family history of hypertension to exercise are not different. Also no complications were observed children during exercise test. Therefore, it was thought that exercise restriction is not required in children with family history of hypertension. Copyright © 2013 by Türkiye Klinikleri.Item Some characterizations of timelike curves according to bishop frame in minkowski 3-space(2013) Kocayiǧit H.; Özdemir A.; Çetin M.; Arda B.In this study, we give some characterizations of timelike curves according to Bishop Frame in Minkowski 3-space E13 by using Laplacian operator and Levi-Civita connection.Item Assessment of pulmonary artery pressure and right ventricular function in children with adenotonsillar hypertrophy using different parameters(Elsevier Ireland Ltd, 2014) Çetin M.; Yilmaz M.; Özen S.; Bozan N.; Coşkun T.Objective: Our aim was comparison of preoperative and postoperative right ventricular functions of children with adenotonsillar hypertrophy (ATH) who have findings of upper airway obstruction, using new echocardiographic parameters. Methods: Forty-one children who have admitted to our hospital with symptoms suggestive of upper airway obstruction, whose history and physical examination findings suggest upper airway obstruction and who have undergone adenoidectomy/adenotonsillectomy and 40 healthy children, all of whom between 2 and 12 years of age, were included in the study. Patient group was evaluated by pulsed wave tissue Doppler echocardiography as well as with conventional echocardiography before the operation and 6 months after the operation. Results: Of 41 children in study group, 26 (63.4%) had adenotonsillectomy and 15 (36.6%) had adenoidectomy. Tricuspid annular plane systolic excursion (TAPSE) was significantly lower in preoperative group compared to control group (18.46. ±. 1.67, 19.77. ±. 1.62; p=0.000, respectively). Myocardial performance index (MPI) was significantly higher in preoperative group than postoperative and control group (0.40. ±. 0.07, 0.36. ±. 0.06, 0.35. ±. 0.07; p= 0.032, respectively). Tricuspid isovolumic acceleration (TIVA) was significantly lower in preoperative group than preoperative and control group (2.97. ±. 0.8, 3.43. ±. 0.7, 3.43. ±. 0.9; p= 0.020, respectively). Disappearance of this difference was found between postoperative and control groups (p= 0.984). Pulmonary acceleration time (PAcT) was found to be significantly lower in preoperative group compared to postoperative and control group (109.68. ±. 18.03, 118.93. ±. 17.46, 120.0. ±. 14.07; p= 0.010, respectively). Mean pulmonary artery pressure (mPAP) was significantly higher in preoperative group than control group (29.64. ±. 8.11, 24.95. ±. 6.33; p= 0.010, respectively). In postoperative group mPAP was found to be similar to control group (25.48. ±. 7.85, 24.95. ±. 6.33; p= 0.740, respectively). Conclusions: TAPSE, PAcT, MPI and TIVA are useful markers for evaluation of preoperative and postoperative ventricular function in children with ATH who have findings of upper airway obstruction. We think that using these practical and easy-to perform parameters may be relevant for evaluation and postoperative follow-up of patients with ATH who have findings of upper airway obstruction. Besides adenotonsillectomy is a beneficial treatment option for these patients. © 2014 Elsevier Ireland Ltd.Item Lucas polynomial approach for system of high-order linear differential equations and residual error estimation(Hindawi Publishing Corporation, 2015) Çetin M.; Sezer M.; Güler C.An approximation method based on Lucas polynomials is presented for the solution of the system of high-order linear differential equations with variable coefficients under the mixed conditions. This method transforms the system of ordinary differential equations (ODEs) to the linear algebraic equations system by expanding the approximate solutions in terms of the Lucas polynomials with unknown coefficients and by using the matrix operations and collocation points. In addition, the error analysis based on residual function is developed for present method. To demonstrate the efficiency and accuracy of the method, numerical examples are given with the help of computer programmes written in Maple and Matlab. © 2015 Muhammed Çetin et al.Item An efficient method based on lucas polynomials for solving high-order linear boundary value problems(Gazi Universitesi, 2015) Çetin M.; Sezer M.; Kocayiğit H.In this paper, a collocation method based on Lucas polynomials for solving high-order linear differential equations with variable coefficients under the boundary conditions is presented by transforming the problem into a system of linear algebraic equations with Lucas coefficients. The proposed approach is applied to fourth, fifth, sixth and eighth-order two-point boundary values problems occurring in science and engineering, and compared by existing methods. The technique gives better approximations than other methods, and has a lower computational cost. In addition, the error analysis based on residual function is developed for the present method and the improved approximate solution is obtained. Moreover, numerical examples are included to illustrate the practical usefulness and efficiency of the method. © 2015, Gazi University Eti Mahallesi. All rights reserved.Item Idiopathic chest pain in children: Is it gastroesophageal reflux disease?(Ortadog u Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2016) Çetin M.; Yurttaş Ö.; Gözkeser E.; Coşkun Ş.; Kasirga E.Objective: Causes of chest pain in children, rarely due to cardiac disease and usually described as idiopathic, account for 20% to 45% of all cases. In this study, we investigated the frequency of gastroesophageal reflux in children with noncardiac chest pain and the characteristics of the pain. Material and Methods: Children with at least two episodes per month of chest pain for a maximum of six months were enrolled in the study. After diagnostic evaluation excluded a cardiac source of chest pain, all patients underwent 24-hour pH monitoring. Characteristics of chest pain and other symptoms were recorded daily by the patients or their parents using the symptom diary. Lansoprazole treatment was administered to patients diagnosed as having gastroesophageal reflux disease. Then, the results of the lansoprazole treatment were evaluated on the basis of the presence of chest pain and other symptoms at the second month after the completion of therapy. Results: Thirty-one children (17 boys and 14 girls) aged between eight and 18 years (11.6±2.4 years) with the primary complaint of chest pain were studied. Based on the 24-hour pH monitoring test results, eight patients (25.8%) for distal sensor and six patients (19.4%) for proximal sensor were defined as Gastroesophageal Reflux Disease (GERD)-positive. No significant difference was noted for characteristics of chest pain and other symptoms between the GERD-positive and GERD-negative groups. All GERD-positive children became symptom-free after the two-month lansoprazole therapy. Conclusion: The symptoms of GERD-induced chest pain are often non-specific, and can be determined with certainty only by 24-hour pH monitoring, so 24-hour pH monitoring may proposed to all children with idiopathic chest pain. Copyright © 2016 by Tür ki ye Kli nik le ri.Item Perimyocarditis mimicking acute coronary syndrome and intravenous immunoglobulin use: Case report; [Akut Koroner Sendromu Taklit Eden Perimiyokardit ve İntravenöz İmmünglobulin Kullanimi](Ortadog u Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2016) Alkan F.; Paytoncu Ş.; Çetin M.; Coşkun Ş.Perimyocarditis is an inflammatory syndrome characterized by myocardial and partly pericardial involvement. In developed countries, viral infections are the most common cause. The other reasons are idiopathic, bacterial or rheumatic diseases and immune drugs. The findings are subclinical, varies from chest pain, heart failure to death. Treatment is performed according to reasons. Anti-inflammatory drugs are used for signs and symptoms. Intravenous immunoglobulin is preferred in selected cases. In this article, we present a case with chest pain, electrocardiogram changes and elevated cardiac enzymes, exclusion of acute coronary syndrome with computed tomography coronary angiography, determination of diffuse myocardial involvement with cardiac magnetic resonance imaging and showing dramatic improvement with intravenous immunoglobulin for persistent clinical signs. Copyright © 2016 by Tür ki ye Kli nik le ri.Item Timelike curves of constant breadth according to bishop frame in minkowski 3-space(Shiraz University, 2017) Kocayiğit H.; Çetin M.; Evirgen M.Ç.In this study, the timelike curves of constant breadth according to Bishop frame in Minkowski 3-space are investigated. The differential equations characterizing the timelike curves of constant breadth in E13 are given. In addition, it is shown that the timelike curves of constant breadth are related to slant helix in Minkowski 3-space E13. © Shiraz University 2017.Item A rare case of asymptomatic giant right atrial aneurysm: Case report(Ortadog u Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2017) Alkan F.; Bayturan Ö.; Çetin M.; Coşkun Ş.Right atrial aneurysm is a rare abnormality of the heart. This defect is seen in all age groups and is usually diagnosed incidentally. The aneurysm can be asymptomatic or present with symptoms related to supraventricular arrhythmias or thromboembolic phenomenon. We present the case report of a 74-year-old male with right atrial aneurysm which was incidentally detected during echocardiographic evaluation. Copyright © 2017 by Türkiye Klinikleri.Item Successful treatment of abdominal aorto-right atrial fistula by vascular plug: A previously unreported cardiac malformation(Turkish Society of Cardiology, 2017) Alkan F.; Pabuşcu Y.; Çetin M.; Coşkun Ş.[No abstract available]Item Asymmetric dimethylarginine levels and diabetes duration: Relationship with measures of subclinical atherosclerosis and cardiac function in children and adolescents with Type 1 diabetes(SAGE Publications Ltd, 2018) Ersoy B.; Eroğlu N.; Çetin M.; Onur E.; Özkol M.; Coşkun Ş.Aims: We aimed to evaluate asymmetric dimethylarginine levels in young patients with Type 1 diabetes mellitus according to diabetes duration and to examine the relationship between these levels and measures of atherosclerosis and myocardial function. Materials and methods: In total, 83 patients (8.5–22 years) with Type 1 diabetes mellitus were stratified by diabetes duration: 12–60 months (Group 1, n = 27), >60–120 months (Group 2, n = 29) and >120 months (Group 3, n = 27). Asymmetric dimethylarginine levels were assessed. Carotid intima–media thickness was measured. Myocardial function was assessed by M-mode, conventional Doppler and tissue Doppler echocardiography. Results: Asymmetric dimethylarginine level was significantly higher in Group 1, while carotid intima–media thickness was significantly greater in Group 3 (p < 0.05). Tissue Doppler echocardiography showed the ratio of peak early to peak late diastolic myocardial annular velocity decreased significantly in Groups 2 and 3 with a negative correlation with duration (r: −0.310, p = 0.004) and HBA1c levels (r = −0.391, p < 0.001). Myocardial performance index in all groups and isovolumic relaxation time in Group 3 increased significantly. Asymmetric dimethylarginine levels were negatively correlated with carotid intima–media thickness and isovolumic relaxation time (p < 0.05). Conclusion: In contrast to adult diabetics, asymmetric dimethylarginine concentration decreases as diabetes duration increases in young Type 1 diabetic patients and is associated with worsening measures of cardiovascular risk and poorer diastolic function. © 2018, © The Author(s) 2018.Item Outcomes of high-risk breast lesions diagnosed using image-guided core needle biopsy: results from a multicenter retrospective study(Galenos Publishing House, 2023) Oktay A.; Aslan Ö.; Taşkın F.; Tunçbilek N.; İçten S.G.E.; Balcı P.; Arıbal M.E.; Çelik L.; Örgüç İ.Ş.; Demirkazık F.B.; Gültekin S.; Aydın A.M.; Durmaz E.; Kul S.; Binokay F.; Çetin M.; Emlik G.D.; Akpınar M.G.; Voyvoda S.N.K.; Polat A.V.; Akın I.B.; Yıldız Ş.; Poyraz N.; Özsoy A.; Öztekin P.S.; Elverici E.; Bayrak İ.K.; İkizceli T.; Dinç F.; Sezgin G.; Gülşen G.; Tunçbilek I.; Yalçın S.R.; Çolakoğlu G.; Ağlamış S.; Yılmaz R.; Rona G.; Durhan G.; Güner D.C.; Yabul F.Ç.; Karabekmez L.G.; Tutar B.; Göktaş M.; Buğdaycı O.; Suner A.; Özdemir N.Purpose: The clinical management of high-risk lesions using image-guided biopsy is challenging. This study aimed to evaluate the rates at which such lesions were upgraded to malignancy and identify possible predictive factors for upgrading high-risk lesions. Methods: This retrospective multicenter analysis included 1.343 patients diagnosed with high-risk lesions using an image-guided core needle or vacuum-assisted biopsy (VAB). Only patients managed using an excisional biopsy or with at least one year of documented radiological follow-up were included. For each, the Breast Imaging Reporting and Data System (BI-RADS) category, number of samples, needle thickness, and lesion size were correlated with malignancy upgrade rates in different histologic subtypes. Pearson's chi-squared test, the Fisher-Freeman-Halton test, and Fisher's exact test were used for the statistical analyses. Results: The overall upgrade rate was 20.6%, with the highest rates in the subtypes of intraductal papilloma (IP) with atypia (44.7%; 55/123), followed by atypical ductal hyperplasia (ADH) (38.4%; 144/375), lobular neoplasia (LN) (12.7%; 7/55), papilloma without atypia (9.4%; 58/611), flat epithelial atypia (FEA) (8.7%; 10/114), and radial scars (RSs) (4.6%; 3/65). There was a significant relationship between the upgrade rate and BI-RADS category, number of samples, and lesion size Lesion size was the most predictive factor for an upgrade in all subtypes. Conclusion: ADH and atypical IP showed considerable upgrade rates to malignancy, requiring surgical excision. The LN, IP without atypia, pure FEA, and RS subtypes showed lower malignancy rates when the BI-RADS category was lower and in smaller lesions that had been adequately sampled using VAB. After being discussed in a multidisciplinary meeting, these cases could be managed with follow-up instead of excision. © 2023, Galenos Publishing House. All rights reserved.Item Normal Values of Echocardiographic Parameters Indicating Right Ventricular Systolic Functions in 607 Healthy Children(Brieflands, 2023) Yılmaz M.; Çetin M.; Dundar P.E.; Coşkun Ş.Background: This study aimed to define the normal ranges of echocardiographic parameters that are used to evaluate right ventricular systolic functions. Methods: A total of 607 children within the age range of 0-18 years without any cardiac pathology or chronic disorders were included in the study. The study population was categorized into different age groups and underwent transthoracic echocardiog-raphy. In this study, tricuspid annular plane systolic excursion (TAPSE), tricuspid annular peak systolic velocity (TAPSV), and right ventricular myocardial performance index (RVMPI) values were measured. Results: There was no statistically significant difference between the mean TAPSE and TAPSV values of male and female subjects. The mean RVMPI was higher in females than in males. The study population was categorized into nine groups according to their age. The TAPSE, TAPSV, and RVMPI values were calculated for each group. Additionally, the 5th, 10th, 25th, 50th, 75th, 90th, and 95th percentiles, and ± 2 standard deviation (SD) and ± 3 SD values of TAPSE measurements were calculated for each age group. The study population was divided into eight groups according to their body surface area (BSA). Moreover, the 5th, 10th, 25th, 50th, 75th, 90th, and 95th percentiles of TAPSE measurements were calculated. There was a strong positive correlation between TAPSE and BSA. The TAPSE was also positively correlated with TAPSV but not with RVMPI. Conclusions: This study determined the normal values for TAPSV and RVMPI. It is important to have knowledge of the normal ranges of these parameters to recognize right ventricular dysfunction early in various cardiac disorders. © 2023, Author(s).